Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, Kiyotake Suenaga

Research output: Contribution to journalArticle

6 Citations (Scopus)


Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

Original languageEnglish
Pages (from-to)4213-4216
Number of pages4
JournalTetrahedron Letters
Issue number37
Publication statusPublished - 2016 Sep 14



  • Depsipeptide
  • Marine cyanobacteria
  • Okeania
  • Urumamide
  • β-Amino acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this