Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp.

Yuki Kanamori, Arihiro Iwasaki, Shinpei Sumimoto, Kiyotake Suenaga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Urumamide, a novel cyclic depsipeptide that contains a β-amino acid, was isolated from a marine cyanobacterium Okeania sp. Its gross structure was determined by spectroscopic analyses, and the absolute configuration was established based on Marfey's analyses and chiral HPLC analyses of hydrolysis products. Biologically, urumamide inhibited the growth of human cancer cells. In addition, urumamide inhibited chymotrypsin.

Original languageEnglish
Pages (from-to)4213-4216
Number of pages4
JournalTetrahedron Letters
Volume57
Issue number37
DOIs
Publication statusPublished - 2016 Sep 14

Fingerprint

Depsipeptides
Chymotrypsin
Cyanobacteria
Hydrolysis
High Pressure Liquid Chromatography
Cells
Amino Acids
Growth
Neoplasms

Keywords

  • Depsipeptide
  • Marine cyanobacteria
  • Okeania
  • Urumamide
  • β-Amino acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Urumamide, a novel chymotrypsin inhibitor with a β-amino acid from a marine cyanobacterium Okeania sp. / Kanamori, Yuki; Iwasaki, Arihiro; Sumimoto, Shinpei; Suenaga, Kiyotake.

In: Tetrahedron Letters, Vol. 57, No. 37, 14.09.2016, p. 4213-4216.

Research output: Contribution to journalArticle

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