Abstract
Carbon Monoxide (CO), at low concentrations, can have a variety of positive effects on the body including anti-apoptosis, anti-inflammatory, anti-oxidative and anti-proliferative effects. Although CO has great potential for use as a potent medical bioactive gas, for it to exist in the body in stable form, it must be associated with a carrier. Hemoglobin (Hb) represents a promising material for use as a CO carrier because most of the total CO in the body is stored associated with Hb in red blood cells (RBC). Attempts have been made to develop an Hb-based CO carrying system using RBC and Hb-based artificial oxygen carriers. Some of these have been reported to be safe and to have therapeutic value as a CO donor in preclinical and clinical studies. In the present review, we overview the potential of RBC and Hb-based artificial oxygen carriers as CO carriers based on the currently available literature evidence for their use in pharmaceutical therapy against intractable dis-orders.
Original language | English |
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Pages (from-to) | 2949-2963 |
Number of pages | 15 |
Journal | Current Medicinal Chemistry |
Volume | 27 |
Issue number | 18 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Anti-apoptosis
- Anti-proliferative effects
- Carbon monoxide
- Hemoglobin
- Hemoglobin-based oxygen carriers
- Red blood cell
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Organic Chemistry