Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly-DL-lactic-co-glycolic acid (PLGA)-collagen sponge

Kensuke Ochi, Gouping Chen, Takashi Ushida, Satoshi Gojo, Kaoru Segawa, Hitoshi Tai, Kenju Ueno, Hiroyuki Ohkawa, Taisuke Mori, Akira Yamaguchi, Yoshiaki Toyama, Jun Ichi Hata, Akihiro Umezawa

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73 Citations (Scopus)

Abstract

Control led regeneration of bone or cartilage has recently begun to facilitate a host of novel clinical treatments. An osteoblast line, which we isolated is able to form new bone matrix in vivo within 2 days and exhibits a mature osteoblast phenotype both in vitro and in vivo. Using these cells, we show that cuboidal bones can be generated into a predesigned shaped-bone with high-density bone trabeculae when used in combination with a modified poly -DL-lactic-co-glycolic acid (PLGA)-collagen sponge. PLGA coated with collagen gel serves as a good scaffold for osteoblasts. These results indicate that mature osteoblasts, in combination with a scaffold such as PLGA-collagen sponge, show promise for use in a custom-shaped bone regeneration tool for both basic research into osteogenesis and for development of therapeutic applications.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalJournal of Cellular Physiology
Volume194
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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    Ochi, K., Chen, G., Ushida, T., Gojo, S., Segawa, K., Tai, H., Ueno, K., Ohkawa, H., Mori, T., Yamaguchi, A., Toyama, Y., Hata, J. I., & Umezawa, A. (2003). Use of isolated mature osteoblasts in abundance acts as desired-shaped bone regeneration in combination with a modified poly-DL-lactic-co-glycolic acid (PLGA)-collagen sponge. Journal of Cellular Physiology, 194(1), 45-53. https://doi.org/10.1002/jcp.10185