TY - JOUR
T1 - Use of OCTA capillary perfusion density measurements to detect and grade macular ischemia
AU - Babiuch, Amy S.
AU - Uchida, Atsuro
AU - Hu, Ming
AU - Khan, Mehnaz
AU - Srivastava, Sunil K.
AU - Singh, Rishi P.
AU - Kaiser, Peter K.
AU - Rachtiskaya, Aleksandra
AU - Reese, Jamie L.
AU - Ehlers, Justis P.
N1 - Funding Information:
Originally submitted May 13, 2019. Revision received May 13, 2019. Accepted for publication October 25, 2019. Presented at the Retina World Congress 2019 meeting, March 21-24, 2019, Fort Lauderdale, FL. Supported by an unrestricted travel grant from Alcon Novartis Hida Memorial Award 2015 funded by Alcon Japan Ltd. (AU); NIH/NEI K23-EY022947-01A1 (JPE); Ohio Department of Development TECH-13-059 (JPE, SKS); and Research to Prevent Blindness (Cole Eye Institutional Grant). Dr. Babiuch is a consultant for Genentech and receives research support from Regeneron. Dr. Srivastava is a consultant for Bausch + Lomb, Zeiss, Leica, and Santen; has received research support from Allergan, and has received personal fees from Bioptigen and Synergetics. Dr. Singh is a consultant for Zeiss, Genentech, Regeneron, Thrombogenics, and Alcon. Dr. Ehlers is a consultant for Zeiss, Santen, Novartis, Roche, and Allergan; is a consultant for and has received research funding from Thrombogenics, Genentech, Alcon, and Aerpio; and is a consultant for and has received personal fees from Biotigen and Leica. The remaining authors report no relevant financial disclosures. Address correspondence to Justis P. Ehlers, MD, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i30, Cleveland, OH 44195; email: ehlersj@ccf.org. doi: 10.3928/23258160-20200401-04
Publisher Copyright:
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PY - 2020/4
Y1 - 2020/4
N2 - BACKGROUND AND OBJECTIVE: To compare optical coherence tomography angiography (OCTA) capillary perfusion density (CPD) measurements of normal eyes and eyes with macular ischemia (MI). PATIENTS AND METHODS: AVATAR is an institutional review board-Approved, prospective, observational imaging study using the Avanti RTVue XR HD. OCTA reports were reviewed for the presence of MI. Qualitative MI grading was performed, and CPD metrics in the superficial and deep fovea and parafovea were analyzed. A normal eye cohort was identified for comparative assessment. RESULTS: The MI and normal cohorts included 55 and 58 eyes, respectively. Compared to normal eyes, eyes with MI had significantly lower CPD values in all regions. There was a statistically significant correlation between qualitative MI grade and VA in the superficial (P = .003) and deep plexuses (P = .029). Only deep parafoveal CPD values demonstrated correlation with VA (P = .043). CONCLUSIONS: Eyes with MI determined by masked qualitative OCTA grading demonstrated significantly reduced CPD values compared to normal eyes. Categorical assessment of MI severity correlated with VA.
AB - BACKGROUND AND OBJECTIVE: To compare optical coherence tomography angiography (OCTA) capillary perfusion density (CPD) measurements of normal eyes and eyes with macular ischemia (MI). PATIENTS AND METHODS: AVATAR is an institutional review board-Approved, prospective, observational imaging study using the Avanti RTVue XR HD. OCTA reports were reviewed for the presence of MI. Qualitative MI grading was performed, and CPD metrics in the superficial and deep fovea and parafovea were analyzed. A normal eye cohort was identified for comparative assessment. RESULTS: The MI and normal cohorts included 55 and 58 eyes, respectively. Compared to normal eyes, eyes with MI had significantly lower CPD values in all regions. There was a statistically significant correlation between qualitative MI grade and VA in the superficial (P = .003) and deep plexuses (P = .029). Only deep parafoveal CPD values demonstrated correlation with VA (P = .043). CONCLUSIONS: Eyes with MI determined by masked qualitative OCTA grading demonstrated significantly reduced CPD values compared to normal eyes. Categorical assessment of MI severity correlated with VA.
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U2 - 10.3928/23258160-20200401-04
DO - 10.3928/23258160-20200401-04
M3 - Article
C2 - 32348532
AN - SCOPUS:85084276380
SN - 2325-8160
VL - 51
SP - S30-S36
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
IS - 4
ER -