Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma

A case report

Wataru Yamagami, Kouji Banno, Makiko Kawaguchi, Megumi Yanokura, Yoshiko Kuwabara, Nobumaru Hirao, Nobuyuki Susumu, Katsumi Tsukazaki, Daisuke Aoki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ovarian mature cystic teratoma. Case Report: The patient was a 70-year-old female with an ovarian tumor, pleural effusion, carcinomatous ascites and a chest wall tumor. The histopathological diagnosis was adenocarcinoma, mature cystic teratoma with malignant transformation, stage IV. Paclitaxel/carboplatin therapy was selected as adjuvant chemotherapy based on CD-DST results. Upon completion of 6 courses, no increases in carcinomatous ascites or recurrent lesions were evident, and the chest wall tumor had disappeared completely. Conclusion: The CD-DST may be particularly useful for selecting preoperative chemotherapeutic drugs for patients with ovarian cancer in which the histological type of the primary tumor is unknown.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalChemotherapy
Volume53
Issue number2
DOIs
Publication statusPublished - 2007 Mar

Fingerprint

Teratoma
Adenocarcinoma
Collagen
Gels
Pharmaceutical Preparations
Thoracic Wall
Neoplasms
Adjuvant Chemotherapy
Ascites
Ovarian Neoplasms
Antitumor Drug Screening Assays
Unknown Primary Neoplasms
Carboplatin
Pleural Effusion
Paclitaxel
Cell Count
Therapeutics

Keywords

  • Adenocarcinoma
  • Adjuvant chemotherapy
  • Collagen gel droplet embedded culture drug sensitivity test
  • Mature cystic teratoma

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma : A case report. / Yamagami, Wataru; Banno, Kouji; Kawaguchi, Makiko; Yanokura, Megumi; Kuwabara, Yoshiko; Hirao, Nobumaru; Susumu, Nobuyuki; Tsukazaki, Katsumi; Aoki, Daisuke.

In: Chemotherapy, Vol. 53, No. 2, 03.2007, p. 137-141.

Research output: Contribution to journalArticle

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AU - Yanokura, Megumi

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