Use of Thrombolysis in Myocardial Infarction Risk Score to predict bleeding complications in patients with unstable angina and non-ST elevation myocardial infarction undergoing percutaneous coronary intervention

Yohei Numasawa, Shun Kosaka, Hiroaki Miyata, Akio Kawamura, Shigetaka Noma, Masahiro Suzuki, Susumu Nakagawa, Yukihiko Momiyama, Toshiyuki Takahashi, Yuji Sato, Keiichi Fukuda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Thrombolysis in myocardial infarction (TIMI) is a prognostic score developed for managing the high risk of cardiac events immediately after unstable angina and non-ST elevation myocardial infarction (UA/NSTEMI). In Asian populations that have a higher rate of bleeding complications, data about TIMI score are lacking. Using a Japanese multicenter registry, we investigated the impact of utilizing TIMI score in UA/NSTEMI patients, focusing on bleeding complications. The TIMI score was calculated for 587 patients who underwent percutaneous coronary intervention (PCI) for UA/NSTEMI (2008-2010). They were classified into low-risk (TIMI score 0-2, N = 268, 45.6 %), intermediate-risk (TIMI score 3-4, N = 264, 45.0 %) and high-risk (TIMI score 5-7, N = 55, 9.4 %) groups; patient characteristics for each group were statistically analyzed. The patients in the higher TIMI score group were older (p < 0.001), had lower GFR (p = 0.021) and hemoglobin level after PCI (p < 0.001), and severe coronary disease pattern (p = 0.014 and p = 0.023, respectively, for left main and three-vessel disease). The TIMI score was significantly associated with requirement of blood transfusion (low-risk, moderate-risk, and high-risk groups: 1.1, 4.2, and 7.3 %, respectively; p = 0.021), and the incidence of access site bleeding (1.1, 2.7, and 5.5 %, p = 0.112). The TIMI score might aid in subjectively quantifying the risk of in-hospital complication rates such as access site bleeding.

Original languageEnglish
Pages (from-to)242-249
Number of pages8
JournalCardiovascular Intervention and Therapeutics
Volume28
Issue number3
DOIs
Publication statusPublished - 2013 Jul

Fingerprint

Unstable Angina
Percutaneous Coronary Intervention
Myocardial Infarction
Hemorrhage
Non-ST Elevated Myocardial Infarction
Blood Transfusion
Coronary Disease
Registries
Hemoglobins
Incidence

Keywords

  • Coronary artery disease
  • Percutaneous coronary intervention
  • TIMI score

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Use of Thrombolysis in Myocardial Infarction Risk Score to predict bleeding complications in patients with unstable angina and non-ST elevation myocardial infarction undergoing percutaneous coronary intervention. / Numasawa, Yohei; Kosaka, Shun; Miyata, Hiroaki; Kawamura, Akio; Noma, Shigetaka; Suzuki, Masahiro; Nakagawa, Susumu; Momiyama, Yukihiko; Takahashi, Toshiyuki; Sato, Yuji; Fukuda, Keiichi.

In: Cardiovascular Intervention and Therapeutics, Vol. 28, No. 3, 07.2013, p. 242-249.

Research output: Contribution to journalArticle

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abstract = "Thrombolysis in myocardial infarction (TIMI) is a prognostic score developed for managing the high risk of cardiac events immediately after unstable angina and non-ST elevation myocardial infarction (UA/NSTEMI). In Asian populations that have a higher rate of bleeding complications, data about TIMI score are lacking. Using a Japanese multicenter registry, we investigated the impact of utilizing TIMI score in UA/NSTEMI patients, focusing on bleeding complications. The TIMI score was calculated for 587 patients who underwent percutaneous coronary intervention (PCI) for UA/NSTEMI (2008-2010). They were classified into low-risk (TIMI score 0-2, N = 268, 45.6 {\%}), intermediate-risk (TIMI score 3-4, N = 264, 45.0 {\%}) and high-risk (TIMI score 5-7, N = 55, 9.4 {\%}) groups; patient characteristics for each group were statistically analyzed. The patients in the higher TIMI score group were older (p < 0.001), had lower GFR (p = 0.021) and hemoglobin level after PCI (p < 0.001), and severe coronary disease pattern (p = 0.014 and p = 0.023, respectively, for left main and three-vessel disease). The TIMI score was significantly associated with requirement of blood transfusion (low-risk, moderate-risk, and high-risk groups: 1.1, 4.2, and 7.3 {\%}, respectively; p = 0.021), and the incidence of access site bleeding (1.1, 2.7, and 5.5 {\%}, p = 0.112). The TIMI score might aid in subjectively quantifying the risk of in-hospital complication rates such as access site bleeding.",
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AU - Miyata, Hiroaki

AU - Kawamura, Akio

AU - Noma, Shigetaka

AU - Suzuki, Masahiro

AU - Nakagawa, Susumu

AU - Momiyama, Yukihiko

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AU - Fukuda, Keiichi

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