Usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base: Comparison with FDG-PET

Shin Ito, Junkichi Yokoyama, Hitoshi Yoshimoto, Masaki Yazawa, Kubota Kazuo, Makoto Hanaguri, Shinichi Ohba, Mitsuhisa Fujimaki, Katsuhisa Ikeda

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5 Citations (Scopus)

Abstract

Background: Choline is a new PET tracer that is useful for the detection of malignant tumor. Choline is a precursor of the biosynthesis of phosphatidylcholine, a major phospholipid in the cell membrane of eukaryotic cells. Malignant tumors have an elevated level of phosphatidylcholine in cell membrane. Thus, choline is a marker of tumor malignancy.Method: The patient was a 51-year-old man with repeated recurrent hemangiopericytoma in the skull base. We performed Choline-PET in this patient after various treatments and compared findings with those of FDG-PET.Results: Choline accumulated in this tumor, but FDG did not accumulate. We diagnosed this tumor as residual hemangiopericytoma and performed the resection of the residual tumor. FDG-PET is not appropriate for skull base tumor detection because uptake in the brain is very strong.Conclusion: We emphasize the usefulness of Choline-PET for the detection of residual hemangiopericytoma in the skull base after various treatments, compared with FDG-PET.

Original languageEnglish
Article number3
JournalHead and Face Medicine
Volume8
Issue number1
DOIs
Publication statusPublished - 2012 Feb 7

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Keywords

  • Choline-pet
  • Hemangiopericytoma
  • Skull base tumor
  • Skullbase surgery

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Clinical Neurology

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