Usefulness of clinicobiological data obtained prior to cervical lymph node biopsy

Taiji Kawasaki, Koichiro Wasano, Noriomi Suzuki, Sayuri Yamamoto, Kaoru Ogawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: We commonly use data obtained prior to cervical lymph node biopsy for the diagnosis of malignant lymphoma. Based on such data, we can confirm whether a biopsy should be performed in some cases. Currently, the parameters used to indicate a presurgery examination prior to biopsy have been very few. So, we retrospectively analyzed cases of cervical lymph node biopsy. Moreover, we examined the usefulness of clinicobiological data obtained prior to cervical lymph node biopsy to evaluate various factors related to the diagnosis of malignant lymphoma. Methods: This study included 77 patients for whom the initial diagnostic impression was malignant lymphoma before surgery. Of the 77 cases. 40 were diagnosed as having malignant lymphoma and 37 were diagnosed as having non-malignant lymphoma. We performed a case-controlled study to evaluate the differences in clinicobiological data between malignant and non-malignant lymphoma in terms of the following parameters: (l) age, (2) sex, (3) number of white blood cells, (4) white blood cell lymphocyte count, (5) percentage of white blood cell lymphocytes, (6) percentage of eosinophils (%), (7) percentage of monocytes (%), (8) atypical lymphocytes (%), (9) hemoglobin level. (10) lactate dehydrogenase level. (11) C-reactive protein level. (12) soluble interleukin-2 receptor (IL-2R) level, and (13) cytologi- cal findings. We used multivariate and univariate analyses to study the data statistically. Results: 'Hie following 5 factors were found to be significant in a Wilcoxon /-test for malignant lymphoma: Percent-age of white blood cell lymphocytes, sIL-2R level, age, white blood cell lymphocyte count, and cytological findings; these factors were also significant when examined using a Pearson X<sup>2</sup> test. The other factors did not differ significantly between the malignant and non-malignant lymphomas. The percentage of white blood cell lymphocytes and the cytological findings were identified as significant independent factors for the diagnosis of malignant lymphoma in a multivariate analysis, whereas the other factors were not found to be significant. Conclusion: Based on the results of the univariate and multivariate analyses performed in the present study, the decline in the percentage of white blood cell lymphocytes and the cytological findings obtained prior to cervical lymph node biopsy are significant indicators of malignant lymphoma.

Original languageEnglish
Pages (from-to)206-212
Number of pages7
JournalJournal of Otolaryngology of Japan
Volume118
Issue number3
Publication statusPublished - 2015 Mar 1

Fingerprint

Lymphoma
Lymph Nodes
Biopsy
Leukocytes
Lymphocytes
Multivariate Analysis
Lymphocyte Count
Leukocyte Count
Interleukin-2 Receptors
L-Lactate Dehydrogenase
Eosinophils
C-Reactive Protein
Monocytes
Hemoglobins

Keywords

  • Cytological findings
  • Data before biopsy
  • Lymphocyte
  • Malignant lymphoma

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Usefulness of clinicobiological data obtained prior to cervical lymph node biopsy. / Kawasaki, Taiji; Wasano, Koichiro; Suzuki, Noriomi; Yamamoto, Sayuri; Ogawa, Kaoru.

In: Journal of Otolaryngology of Japan, Vol. 118, No. 3, 01.03.2015, p. 206-212.

Research output: Contribution to journalArticle

Kawasaki, T, Wasano, K, Suzuki, N, Yamamoto, S & Ogawa, K 2015, 'Usefulness of clinicobiological data obtained prior to cervical lymph node biopsy', Journal of Otolaryngology of Japan, vol. 118, no. 3, pp. 206-212.
Kawasaki, Taiji ; Wasano, Koichiro ; Suzuki, Noriomi ; Yamamoto, Sayuri ; Ogawa, Kaoru. / Usefulness of clinicobiological data obtained prior to cervical lymph node biopsy. In: Journal of Otolaryngology of Japan. 2015 ; Vol. 118, No. 3. pp. 206-212.
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T1 - Usefulness of clinicobiological data obtained prior to cervical lymph node biopsy

AU - Kawasaki, Taiji

AU - Wasano, Koichiro

AU - Suzuki, Noriomi

AU - Yamamoto, Sayuri

AU - Ogawa, Kaoru

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Introduction: We commonly use data obtained prior to cervical lymph node biopsy for the diagnosis of malignant lymphoma. Based on such data, we can confirm whether a biopsy should be performed in some cases. Currently, the parameters used to indicate a presurgery examination prior to biopsy have been very few. So, we retrospectively analyzed cases of cervical lymph node biopsy. Moreover, we examined the usefulness of clinicobiological data obtained prior to cervical lymph node biopsy to evaluate various factors related to the diagnosis of malignant lymphoma. Methods: This study included 77 patients for whom the initial diagnostic impression was malignant lymphoma before surgery. Of the 77 cases. 40 were diagnosed as having malignant lymphoma and 37 were diagnosed as having non-malignant lymphoma. We performed a case-controlled study to evaluate the differences in clinicobiological data between malignant and non-malignant lymphoma in terms of the following parameters: (l) age, (2) sex, (3) number of white blood cells, (4) white blood cell lymphocyte count, (5) percentage of white blood cell lymphocytes, (6) percentage of eosinophils (%), (7) percentage of monocytes (%), (8) atypical lymphocytes (%), (9) hemoglobin level. (10) lactate dehydrogenase level. (11) C-reactive protein level. (12) soluble interleukin-2 receptor (IL-2R) level, and (13) cytologi- cal findings. We used multivariate and univariate analyses to study the data statistically. Results: 'Hie following 5 factors were found to be significant in a Wilcoxon /-test for malignant lymphoma: Percent-age of white blood cell lymphocytes, sIL-2R level, age, white blood cell lymphocyte count, and cytological findings; these factors were also significant when examined using a Pearson X2 test. The other factors did not differ significantly between the malignant and non-malignant lymphomas. The percentage of white blood cell lymphocytes and the cytological findings were identified as significant independent factors for the diagnosis of malignant lymphoma in a multivariate analysis, whereas the other factors were not found to be significant. Conclusion: Based on the results of the univariate and multivariate analyses performed in the present study, the decline in the percentage of white blood cell lymphocytes and the cytological findings obtained prior to cervical lymph node biopsy are significant indicators of malignant lymphoma.

AB - Introduction: We commonly use data obtained prior to cervical lymph node biopsy for the diagnosis of malignant lymphoma. Based on such data, we can confirm whether a biopsy should be performed in some cases. Currently, the parameters used to indicate a presurgery examination prior to biopsy have been very few. So, we retrospectively analyzed cases of cervical lymph node biopsy. Moreover, we examined the usefulness of clinicobiological data obtained prior to cervical lymph node biopsy to evaluate various factors related to the diagnosis of malignant lymphoma. Methods: This study included 77 patients for whom the initial diagnostic impression was malignant lymphoma before surgery. Of the 77 cases. 40 were diagnosed as having malignant lymphoma and 37 were diagnosed as having non-malignant lymphoma. We performed a case-controlled study to evaluate the differences in clinicobiological data between malignant and non-malignant lymphoma in terms of the following parameters: (l) age, (2) sex, (3) number of white blood cells, (4) white blood cell lymphocyte count, (5) percentage of white blood cell lymphocytes, (6) percentage of eosinophils (%), (7) percentage of monocytes (%), (8) atypical lymphocytes (%), (9) hemoglobin level. (10) lactate dehydrogenase level. (11) C-reactive protein level. (12) soluble interleukin-2 receptor (IL-2R) level, and (13) cytologi- cal findings. We used multivariate and univariate analyses to study the data statistically. Results: 'Hie following 5 factors were found to be significant in a Wilcoxon /-test for malignant lymphoma: Percent-age of white blood cell lymphocytes, sIL-2R level, age, white blood cell lymphocyte count, and cytological findings; these factors were also significant when examined using a Pearson X2 test. The other factors did not differ significantly between the malignant and non-malignant lymphomas. The percentage of white blood cell lymphocytes and the cytological findings were identified as significant independent factors for the diagnosis of malignant lymphoma in a multivariate analysis, whereas the other factors were not found to be significant. Conclusion: Based on the results of the univariate and multivariate analyses performed in the present study, the decline in the percentage of white blood cell lymphocytes and the cytological findings obtained prior to cervical lymph node biopsy are significant indicators of malignant lymphoma.

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