Usefulness of Hematological Inflammatory Markers in Predicting Severe Side-effects from Induction Chemotherapy in Head and Neck Cancer Patients

Takuya Mikoshiba, Shin Saito, Yuichi Ikari, Nana Nakahara, Fumihiro Ito, Yoshihiro Watanabe, Mariko Sekimizu, Yorihisa Imanishi, Kaoru Ogawa, Hiroyuki Ozawa

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1 Citation (Scopus)


Background: Induction chemotherapy (IC) for head and neck cancer (HNC) often causes severe side-effects. However, it has still been challenging to predict the adverse events. The present study aimed to evaluate the role of hematological inflammatory markers in predicting severe side-effects caused by IC. Materials and Methods: A total of 54 HNC patients who underwent IC were enrolled. The association between severe side-effects and pre-treatment hematological inflammatory markers [the C-reactive protein (CRP) to albumin ratio (CAR), the modified Glasgow Prognostic Score (mGPS), the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR)] were evaluated. Results: In the univariate analysis, the incidence of whole severe side-effects (grade 4), febrile neutropenia (above grade 3), and hyponatremia (above grade 3) were significantly higher in the high CAR and high GPS groups. Multivariate analysis revealed that high CAR and mGPS were independent predictors of these side-effects. Conclusion: CAR and mGPS were significant predictors of severe side-effects. These data can potentially offer patients an improved quality of life during cancer therapy.

Original languageEnglish
Pages (from-to)3059-3065
Number of pages7
JournalAnticancer research
Issue number6
Publication statusPublished - 2019 Jan 1



  • Hematological inflammatory markers
  • Inflammatory cytokines
  • Oropharyngeal and hypopharyngeal squamous cell carcinoma
  • Severe side-effect
  • TPF therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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