Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage: A case report

Masayuki Tanaka, Minoru Kitago, Nobuyoshi Akiyama, Arifumi Iwamaru, Tatsuya Yamamoto, Fumio Suzuki, Taizo Hibi, Yuta Abe, Hiroshi Yagi, Masahiro Shinoda, Osamu Itano, Kentaro Ogata, Yuukou Kitagawa

Research output: Contribution to journalArticle

Abstract

Isolated metachronous gastrointestinal metastases from advanced-stage lung cancer are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable metachronous gallbladder and small intestinal metastases of lung cancer. An 86-year-old woman was treated for lung cancer with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of melena and anemia. Ultrasonography showed a gallbladder tumor with gastrointestinal hemorrhage, and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2 months after this event, the patient presented again with melena and anemia and was diagnosed with a small intestinal tumor. Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for thyroid transcription factor-1 and cytokeratin 7 confirmed that the two resected tumors were metachronous metastases of the primary lung cancer. The patient died of liver metastases 5 months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for patients with isolated gallbladder and small intestinal metastases diagnosed on the basis of melena that is resistant to conservative treatment.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalWorld Journal of Surgical Oncology
DOIs
Publication statusAccepted/In press - 2015 Feb 18

Fingerprint

Gastrointestinal Hemorrhage
Gallbladder
Lung Neoplasms
Melena
Neoplasm Metastasis
Anemia
T Cell Transcription Factor 1
Keratin-7
Neoplasms
Laparoscopic Cholecystectomy
Small Intestine
Ultrasonography
Staining and Labeling
Liver

Keywords

  • Gastrointestinal hemorrhage
  • Immunohistochemical staining
  • Metachronous gallbladder and small intestinal metastases
  • Primary lung cancer

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage : A case report. / Tanaka, Masayuki; Kitago, Minoru; Akiyama, Nobuyoshi; Iwamaru, Arifumi; Yamamoto, Tatsuya; Suzuki, Fumio; Hibi, Taizo; Abe, Yuta; Yagi, Hiroshi; Shinoda, Masahiro; Itano, Osamu; Ogata, Kentaro; Kitagawa, Yuukou.

In: World Journal of Surgical Oncology, 18.02.2015, p. 1-6.

Research output: Contribution to journalArticle

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