Abstract
Isolated metachronous gastrointestinal metastases from advanced-stage lung cancer are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable metachronous gallbladder and small intestinal metastases of lung cancer. An 86-year-old woman was treated for lung cancer with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of melena and anemia. Ultrasonography showed a gallbladder tumor with gastrointestinal hemorrhage, and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2 months after this event, the patient presented again with melena and anemia and was diagnosed with a small intestinal tumor. Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for thyroid transcription factor-1 and cytokeratin 7 confirmed that the two resected tumors were metachronous metastases of the primary lung cancer. The patient died of liver metastases 5 months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for patients with isolated gallbladder and small intestinal metastases diagnosed on the basis of melena that is resistant to conservative treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | World Journal of Surgical Oncology |
| DOIs | |
| Publication status | Accepted/In press - 2015 Feb 18 |
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Keywords
- Gastrointestinal hemorrhage
- Immunohistochemical staining
- Metachronous gallbladder and small intestinal metastases
- Primary lung cancer
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage : A case report. / Tanaka, Masayuki; Kitago, Minoru; Akiyama, Nobuyoshi; Iwamaru, Arifumi; Yamamoto, Tatsuya; Suzuki, Fumio; Hibi, Taizo; Abe, Yuta; Yagi, Hiroshi; Shinoda, Masahiro; Itano, Osamu; Ogata, Kentaro; Kitagawa, Yuukou.
In: World Journal of Surgical Oncology, 18.02.2015, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Usefulness of immunohistochemical studies in diagnosing metachronous gallbladder and small intestinal metastases from lung cancer with gastrointestinal hemorrhage
T2 - A case report
AU - Tanaka, Masayuki
AU - Kitago, Minoru
AU - Akiyama, Nobuyoshi
AU - Iwamaru, Arifumi
AU - Yamamoto, Tatsuya
AU - Suzuki, Fumio
AU - Hibi, Taizo
AU - Abe, Yuta
AU - Yagi, Hiroshi
AU - Shinoda, Masahiro
AU - Itano, Osamu
AU - Ogata, Kentaro
AU - Kitagawa, Yuukou
PY - 2015/2/18
Y1 - 2015/2/18
N2 - Isolated metachronous gastrointestinal metastases from advanced-stage lung cancer are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable metachronous gallbladder and small intestinal metastases of lung cancer. An 86-year-old woman was treated for lung cancer with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of melena and anemia. Ultrasonography showed a gallbladder tumor with gastrointestinal hemorrhage, and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2 months after this event, the patient presented again with melena and anemia and was diagnosed with a small intestinal tumor. Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for thyroid transcription factor-1 and cytokeratin 7 confirmed that the two resected tumors were metachronous metastases of the primary lung cancer. The patient died of liver metastases 5 months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for patients with isolated gallbladder and small intestinal metastases diagnosed on the basis of melena that is resistant to conservative treatment.
AB - Isolated metachronous gastrointestinal metastases from advanced-stage lung cancer are rarely diagnosed on the basis of symptoms and resected. In this report, we present a case of resectable metachronous gallbladder and small intestinal metastases of lung cancer. An 86-year-old woman was treated for lung cancer with resection of the right inferior lobe. Five months after the surgery, she was re-admitted because of melena and anemia. Ultrasonography showed a gallbladder tumor with gastrointestinal hemorrhage, and laparoscopic-assisted cholecystectomy was subsequently performed. However, 2 months after this event, the patient presented again with melena and anemia and was diagnosed with a small intestinal tumor. Therefore, laparoscopic-assisted partial resection of the small intestine was performed. Immunohistochemical staining for thyroid transcription factor-1 and cytokeratin 7 confirmed that the two resected tumors were metachronous metastases of the primary lung cancer. The patient died of liver metastases 5 months after the last surgery. Our experience with this case suggests that surgical resection might not be curative but palliative for patients with isolated gallbladder and small intestinal metastases diagnosed on the basis of melena that is resistant to conservative treatment.
KW - Gastrointestinal hemorrhage
KW - Immunohistochemical staining
KW - Metachronous gallbladder and small intestinal metastases
KW - Primary lung cancer
UR - http://www.scopus.com/inward/record.url?scp=84928687899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928687899&partnerID=8YFLogxK
U2 - 10.1186/s12957-015-0435-7
DO - 10.1186/s12957-015-0435-7
M3 - Article
C2 - 25889744
AN - SCOPUS:84928687899
SP - 1
EP - 6
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
SN - 1477-7819
ER -