Usefulness of implementing comprehensive pharmaceutical care for metastatic renal cell carcinoma outpatients treated with pazopanib

Maki Todo, Suguru Shirotake, Koshiro Nishimoto, Yota Yasumizu, Gou Kaneko, Hideyuki Kondo, Takashi Okabe, Hideki Makabe, Masafumi Oyama

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: Pazopanib is an effective treatment option for renal cell carcinoma (RCC). However, the therapy is often limited by the appearance of adverse events (AEs), including nausea/vomiting, hepatic impairment, hand-foot syndrome, diarrhea, hypertension and oral mucositis. Early management of AEs is, therefore, extremely important in order to maximize treatment outcomes. Patients and Methods: This non-randomized controlled before-and-after study was carried out to evaluate the effectiveness of our comprehensive pharmaceutical interventions in 37 outpatients receiving pazopanib for RCC (experimental group). Data were compared with those obtained from 13 patients before the start of pharmaceutical intervention (control group). Results: The incidence rates of grade 2 or more nausea and anorexia were significantly lower in the experimental, than in the control group (3% versus 38% for nausea, respectively, p=0.003; 8% versus 46% for anorexia, respectively, p=0.005). Importantly, non-adherence based on patient self-assessment was not observed with intervention (0% versus 38%, p<0.001). Consequently, the median total dose of pazopanib was increased by the intervention (72,600 versus 18,200 mg, p=0.002). Moreover, the median time to treatment failure was significantly longer with intervention than before (10.2 versus 1.7 months, HR=0.23, 95% CI=0.110-0.499, p<0.001). These findings suggest that our interventions are highly effective for enhancing treatment outcomes.

Original languageEnglish
Pages (from-to)999-1004
Number of pages6
JournalAnticancer research
Issue number2
Publication statusPublished - 2019 Feb
Externally publishedYes


  • Adverse events
  • Metastasis
  • Pazopanib
  • Pharmaceutical care
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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