Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: A multicenter prospective study

Shigeatsu Endo, Naoki Aikawa, Seitaro Fujishima, Isao Sekine, Kazuhiro Kogawa, Yasuhiro Yamamoto, Shigeki Kushimoto, Hidekazu Yukioka, Noboru Kato, Kyoichi Totsuka, Ken Kikuchi, Toshiaki Ikeda, Kazumi Ikeda, Hiroyuki Yamada, Kazuaki Harada, Shinji Satomura

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Abstract

Procalcitonin serum level has been recommended as a new marker of bacterial infectious diseases. The aim of this prospective, multicenter study was to determine the clinical usefulness of procalcitonin in differentiating patients with sepsis from those with severe sepsis. Eighty-two patients were enrolled: 20 without systemic inflammatory response syndrome (SIRS), 9 with SIRS, 34 with sepsis, and 19 with severe sepsis. The patients with severe sepsis had significantly higher procalcitonin levels (median, 36.1 ng/ml) than those with sepsis (median, 0.6 ng/ml). With a procalcitonin cutoff value of 2.0 ng/ml, sensitivity for the detection of severe sepsis and specificity for the detection of sepsis were 94.7% and 78.1%, respectively. A good correlation was found between the serum procalcitonin level and the Sepsis-Related Organ Failure Assessment (SOFA) score (r = 0.680), although no correlation was found between the C-reactive protein (CRP) level and the SOFA score. In conclusion, the procalcitonin serum level may be useful not only for aiding the diagnosis of sepsis but also for discriminating between sepsis and severe sepsis.

Original languageEnglish
Pages (from-to)244-249
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume14
Issue number3
DOIs
Publication statusPublished - 2008 Jun

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Keywords

  • APACHE II score
  • Procalcitonin
  • SIRS
  • SOFA score
  • Sepsis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Endo, S., Aikawa, N., Fujishima, S., Sekine, I., Kogawa, K., Yamamoto, Y., Kushimoto, S., Yukioka, H., Kato, N., Totsuka, K., Kikuchi, K., Ikeda, T., Ikeda, K., Yamada, H., Harada, K., & Satomura, S. (2008). Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: A multicenter prospective study. Journal of Infection and Chemotherapy, 14(3), 244-249. https://doi.org/10.1007/s10156-008-0608-1