Usefulness of serum cystatin C for the diagnosis of impaired renal function

Chinami Oyabu, Nobuhide Hayashi, Daisuke Sugiyama, Mitio Umezu, Masahiko Mukai, Seiji Kawano, Shunichi Kumagai

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Abstract

Creatinine clearance (Ccr) is generally used as a halmark of glomerular filtration rate (GFR) in clinical medicine. Recently, it has been suggested that serum cystatin C measurement in serum reflects GFR. We compared serum cystatin C, serum creatinine, and serum beta2-microgrobrin in 70 patients with renal diseases in reference to creatinine clearance. The correlation between Ccr and 1/cystatin C was higher (r = 0.830) than that between Ccr and 1/serum creatinine (r = 0.789) or 1/serum beta2-microgroburin (r = 0.732). The levels of serum cystatin C in patients with Ccr ranging from 51 to 70 ml/min were significantly higher than those in patients with Ccr ranging more than 91 ml/min. Receiver-operated characteristic (ROC) analysis revealed that serum cystatin C showed the highest area under the curve among the three when Ccr = 90 ml/min was used as the cutoff point. We conclude that serum cystatin C is more useful than serum creatinine to detect early renal dysfunction.

Original languageEnglish
Pages (from-to)1204-1208
Number of pages5
JournalRinsho byori. The Japanese journal of clinical pathology
Volume54
Issue number12
Publication statusPublished - 2006 Dec
Externally publishedYes

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Cystatin C
Creatinine
Kidney
Serum
Glomerular Filtration Rate
Clinical Medicine
Area Under Curve

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Oyabu, C., Hayashi, N., Sugiyama, D., Umezu, M., Mukai, M., Kawano, S., & Kumagai, S. (2006). Usefulness of serum cystatin C for the diagnosis of impaired renal function. Rinsho byori. The Japanese journal of clinical pathology, 54(12), 1204-1208.

Usefulness of serum cystatin C for the diagnosis of impaired renal function. / Oyabu, Chinami; Hayashi, Nobuhide; Sugiyama, Daisuke; Umezu, Mitio; Mukai, Masahiko; Kawano, Seiji; Kumagai, Shunichi.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 54, No. 12, 12.2006, p. 1204-1208.

Research output: Contribution to journalArticle

Oyabu, C, Hayashi, N, Sugiyama, D, Umezu, M, Mukai, M, Kawano, S & Kumagai, S 2006, 'Usefulness of serum cystatin C for the diagnosis of impaired renal function', Rinsho byori. The Japanese journal of clinical pathology, vol. 54, no. 12, pp. 1204-1208.
Oyabu, Chinami ; Hayashi, Nobuhide ; Sugiyama, Daisuke ; Umezu, Mitio ; Mukai, Masahiko ; Kawano, Seiji ; Kumagai, Shunichi. / Usefulness of serum cystatin C for the diagnosis of impaired renal function. In: Rinsho byori. The Japanese journal of clinical pathology. 2006 ; Vol. 54, No. 12. pp. 1204-1208.
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