Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation

Satomi Ito, Jun Taguchi, Jun Kato, Aya Nakaya, Takayoshi Tachibana, Sachiya Takemura, Ayumi Sano, Masahiko Ohata, Yoshiaki Ishigatsubo, Hiroyuki Fujita

Research output: Contribution to journalArticle

Abstract

Sinusoidal obstruction syndrome (SOS) was originally defined as a clinical syndrome occurring by three weeks after transplantation; however, it occurs even after three or more weeks, and such cases are called late-onset SOS. We report here a case of late-onset SOS. The patient was a 17-year-old male with acute myeloid leukemia in second complete remission. He received a preparative regimen including busulfan followed by allo-peripheral blood stem cell transplantation from an HLA-matched sibling donor. On day 28 after transplantation, he developed hepatomegaly with pain. On day 33 PAI-1 level was increased. Two days later ascites developed, leading to a diagnosis of late-onset SOS. The symptoms improved with conservative therapy and the level of PAI-1 was normalized. When hepatic impairment appears three or more weeks after transplantation, late-onset SOS should be considered. PAI-1 is a useful marker for the diagnosis and follow up of late-onset SOS.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume51
Issue number1
Publication statusPublished - 2010 Jan
Externally publishedYes

Fingerprint

Hepatic Veno-Occlusive Disease
Delayed Diagnosis
Plasminogen Activator Inhibitor 1
Stem Cell Transplantation
Serum
Transplantation
Peripheral Blood Stem Cell Transplantation
Busulfan
Hepatomegaly
Ascites
Acute Myeloid Leukemia
Siblings
Tissue Donors
Pain
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation. / Ito, Satomi; Taguchi, Jun; Kato, Jun; Nakaya, Aya; Tachibana, Takayoshi; Takemura, Sachiya; Sano, Ayumi; Ohata, Masahiko; Ishigatsubo, Yoshiaki; Fujita, Hiroyuki.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 51, No. 1, 01.2010, p. 69-73.

Research output: Contribution to journalArticle

Ito, Satomi ; Taguchi, Jun ; Kato, Jun ; Nakaya, Aya ; Tachibana, Takayoshi ; Takemura, Sachiya ; Sano, Ayumi ; Ohata, Masahiko ; Ishigatsubo, Yoshiaki ; Fujita, Hiroyuki. / Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation. In: [Rinshō ketsueki] The Japanese journal of clinical hematology. 2010 ; Vol. 51, No. 1. pp. 69-73.
@article{b81432308c474a4c83e67f03d3f91a4b,
title = "Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation",
abstract = "Sinusoidal obstruction syndrome (SOS) was originally defined as a clinical syndrome occurring by three weeks after transplantation; however, it occurs even after three or more weeks, and such cases are called late-onset SOS. We report here a case of late-onset SOS. The patient was a 17-year-old male with acute myeloid leukemia in second complete remission. He received a preparative regimen including busulfan followed by allo-peripheral blood stem cell transplantation from an HLA-matched sibling donor. On day 28 after transplantation, he developed hepatomegaly with pain. On day 33 PAI-1 level was increased. Two days later ascites developed, leading to a diagnosis of late-onset SOS. The symptoms improved with conservative therapy and the level of PAI-1 was normalized. When hepatic impairment appears three or more weeks after transplantation, late-onset SOS should be considered. PAI-1 is a useful marker for the diagnosis and follow up of late-onset SOS.",
author = "Satomi Ito and Jun Taguchi and Jun Kato and Aya Nakaya and Takayoshi Tachibana and Sachiya Takemura and Ayumi Sano and Masahiko Ohata and Yoshiaki Ishigatsubo and Hiroyuki Fujita",
year = "2010",
month = "1",
language = "English",
volume = "51",
pages = "69--73",
journal = "[Rinshō ketsueki] The Japanese journal of clinical hematology",
issn = "0485-1439",
publisher = "Nihon Rinsho Ketsueki Gakkai/Japan Society of Clinical Hematology",
number = "1",

}

TY - JOUR

T1 - Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation

AU - Ito, Satomi

AU - Taguchi, Jun

AU - Kato, Jun

AU - Nakaya, Aya

AU - Tachibana, Takayoshi

AU - Takemura, Sachiya

AU - Sano, Ayumi

AU - Ohata, Masahiko

AU - Ishigatsubo, Yoshiaki

AU - Fujita, Hiroyuki

PY - 2010/1

Y1 - 2010/1

N2 - Sinusoidal obstruction syndrome (SOS) was originally defined as a clinical syndrome occurring by three weeks after transplantation; however, it occurs even after three or more weeks, and such cases are called late-onset SOS. We report here a case of late-onset SOS. The patient was a 17-year-old male with acute myeloid leukemia in second complete remission. He received a preparative regimen including busulfan followed by allo-peripheral blood stem cell transplantation from an HLA-matched sibling donor. On day 28 after transplantation, he developed hepatomegaly with pain. On day 33 PAI-1 level was increased. Two days later ascites developed, leading to a diagnosis of late-onset SOS. The symptoms improved with conservative therapy and the level of PAI-1 was normalized. When hepatic impairment appears three or more weeks after transplantation, late-onset SOS should be considered. PAI-1 is a useful marker for the diagnosis and follow up of late-onset SOS.

AB - Sinusoidal obstruction syndrome (SOS) was originally defined as a clinical syndrome occurring by three weeks after transplantation; however, it occurs even after three or more weeks, and such cases are called late-onset SOS. We report here a case of late-onset SOS. The patient was a 17-year-old male with acute myeloid leukemia in second complete remission. He received a preparative regimen including busulfan followed by allo-peripheral blood stem cell transplantation from an HLA-matched sibling donor. On day 28 after transplantation, he developed hepatomegaly with pain. On day 33 PAI-1 level was increased. Two days later ascites developed, leading to a diagnosis of late-onset SOS. The symptoms improved with conservative therapy and the level of PAI-1 was normalized. When hepatic impairment appears three or more weeks after transplantation, late-onset SOS should be considered. PAI-1 is a useful marker for the diagnosis and follow up of late-onset SOS.

UR - http://www.scopus.com/inward/record.url?scp=77950353186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950353186&partnerID=8YFLogxK

M3 - Article

C2 - 20134143

AN - SCOPUS:77950353186

VL - 51

SP - 69

EP - 73

JO - [Rinshō ketsueki] The Japanese journal of clinical hematology

JF - [Rinshō ketsueki] The Japanese journal of clinical hematology

SN - 0485-1439

IS - 1

ER -