Usefulness of serum plasminogen activator inhibitor-1 for diagnosis and monitoring of late-onset sinusoidal obstruction syndrome after allogeneic stem cell transplantation

Satomi Ito, Jun Taguchi, Jun Kato, Aya Nakaya, Takayoshi Tachibana, Sachiya Takemura, Ayumi Sano, Masahiko Ohata, Yoshiaki Ishigatsubo, Hiroyuki Fujita

Research output: Contribution to journalArticle

Abstract

Sinusoidal obstruction syndrome (SOS) was originally defined as a clinical syndrome occurring by three weeks after transplantation; however, it occurs even after three or more weeks, and such cases are called late-onset SOS. We report here a case of late-onset SOS. The patient was a 17-year-old male with acute myeloid leukemia in second complete remission. He received a preparative regimen including busulfan followed by allo-peripheral blood stem cell transplantation from an HLA-matched sibling donor. On day 28 after transplantation, he developed hepatomegaly with pain. On day 33 PAI-1 level was increased. Two days later ascites developed, leading to a diagnosis of late-onset SOS. The symptoms improved with conservative therapy and the level of PAI-1 was normalized. When hepatic impairment appears three or more weeks after transplantation, late-onset SOS should be considered. PAI-1 is a useful marker for the diagnosis and follow up of late-onset SOS.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
Journal[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume51
Issue number1
Publication statusPublished - 2010 Jan
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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