Usefulness of the Red Blood Cell Distribution Width to Predict Heart Failure in Patients With a Fontan Circulation

Takuro Kojima, Jun Yasuhara, Takashi Kumamoto, Hiroyuki Shimizu, Shigeki Yoshiba, Toshiki Kobayashi, Naokata Sumitomo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The red blood cell distribution width (RDW) is a quantitative measure of the variability in the size of circulating erythrocytes. We aimed to study whether higher levels of the RDW were associated with heart failure in a Fontan circulation and to analyze its clinical value compared to brain natriuretic peptide. This retrospective study included 38 consecutive pediatric patients with a Fontan circulation who underwent routine cardiac catheterization at the International Medical Center, Saitama Medical University from October 2010 to July 2014. We assessed the relation between the RDW and catheterization data such as the central venous pressure (CVP), mixed venous oxygen saturation (SvO2), and cardiac index (CI). The RDW was positively correlated with the CVP (p = 0.0002). The elevated RDW group had a significantly greater CVP than the normal RDW group (p = 0.0003). Also, the RDW was negatively correlated with the SvO2 (p = 0.0004). The elevated RDW group had a significantly less SvO2 than the normal RDW group (p <0.0001). The CI in the elevated RDW group was lower than that in the normal RDW group (p = 0.0421). In the multivariate regression analysis, the RDW was a significant independent predictor of the CVP and SvO2. The BNP level did not have any significant relation with the CVP, SvO2, or CI. The RDW is a convenient and powerful marker for detecting heart failure in a Fontan circulation.

Original languageEnglish
Article number21249
Pages (from-to)965-968
Number of pages4
JournalAmerican Journal of Cardiology
Volume116
Issue number6
DOIs
Publication statusPublished - 2015 Sep 15
Externally publishedYes

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Central Venous Pressure
Erythrocyte Indices
Heart Failure
Erythrocytes
Brain Natriuretic Peptide
Cardiac Catheterization
Catheterization
Multivariate Analysis
Retrospective Studies
Regression Analysis
Pediatrics
Oxygen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kojima, T., Yasuhara, J., Kumamoto, T., Shimizu, H., Yoshiba, S., Kobayashi, T., & Sumitomo, N. (2015). Usefulness of the Red Blood Cell Distribution Width to Predict Heart Failure in Patients With a Fontan Circulation. American Journal of Cardiology, 116(6), 965-968. [21249]. https://doi.org/10.1016/j.amjcard.2015.06.020

Usefulness of the Red Blood Cell Distribution Width to Predict Heart Failure in Patients With a Fontan Circulation. / Kojima, Takuro; Yasuhara, Jun; Kumamoto, Takashi; Shimizu, Hiroyuki; Yoshiba, Shigeki; Kobayashi, Toshiki; Sumitomo, Naokata.

In: American Journal of Cardiology, Vol. 116, No. 6, 21249, 15.09.2015, p. 965-968.

Research output: Contribution to journalArticle

Kojima, T, Yasuhara, J, Kumamoto, T, Shimizu, H, Yoshiba, S, Kobayashi, T & Sumitomo, N 2015, 'Usefulness of the Red Blood Cell Distribution Width to Predict Heart Failure in Patients With a Fontan Circulation', American Journal of Cardiology, vol. 116, no. 6, 21249, pp. 965-968. https://doi.org/10.1016/j.amjcard.2015.06.020
Kojima, Takuro ; Yasuhara, Jun ; Kumamoto, Takashi ; Shimizu, Hiroyuki ; Yoshiba, Shigeki ; Kobayashi, Toshiki ; Sumitomo, Naokata. / Usefulness of the Red Blood Cell Distribution Width to Predict Heart Failure in Patients With a Fontan Circulation. In: American Journal of Cardiology. 2015 ; Vol. 116, No. 6. pp. 965-968.
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