The stereoselective conversion of the naturally occurring optically active cyclitol, L-quebrachitol 2, into antifungal β-methoxyacrylate, oudemansin X 1 is described. This first total synthesis of 1 fully confirmed the proposed absolute configuration of the antibiotic and showed the importance of 2 as a versatile chiral starting material in natural product syntheses.
|Number of pages||6|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - 1993 Dec 1|
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