Utility of birefringence changes due to collagen thermal denaturation rate process analysis: Vessel wall temperature estimation for new short term heating balloon angioplasty

Kenji Kaneko, Natsumi Shimazaki, Maya Gotoh, Eriko Nakatani, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Our photo thermal reaction heating architecture balloon realizes less than 10 s short term heating that can soften vessel wall collagen without damaging surrounding tissue thermally. New thermal balloon angioplasty, photo-thermo dynamic balloon angioplasty (PTDBA) has experimentally shown sufficient opening with 2 atm low pressure dilation and prevention of chronic phase restenosis and acute phase thrombus in vivo. Even though PTDBA has high therapeutic potential, the most efficient heating condition is still under study, because relationship of treatment and thermal dose to vessel wall is not clarified yet. To study and set the most efficient heating condition, we have been working on establishment of temperature history estimation method from our previous experimental results. Heating target of PTDBA, collagen, thermally denatures following rate process. Denaturation is able to be quantified with measured collagen birefringence value. To express the denaturation with equation of rate process, the following ex vivo experiments were performed. Porcine extracted carotid artery was soaked in two different temperature saline baths to enforce constant temperature heating. Higher temperature bath was set to 40 to 80 °C and soaking duration was 5 to 40 s. Samples were observed by a polarizing microscope and a scanning electron microscope. The birefringence was measured by polarizing microscopic system using Brace-Koehler compensator 1/30 A. The measured birefringence showed temperature dependency and quite fit with the rate process equation. We think vessel wall temperature is able to be estimated using the birefringence changes due to thermal denaturation.

Original languageEnglish
Title of host publicationOptical Interactions with Tissue and Cells XVIII
DOIs
Publication statusPublished - 2007 Apr 30
EventOptical Interactions with Tissue and Cells XVIII - San Jose, CA, United States
Duration: 2007 Jan 222007 Jan 24

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6435
ISSN (Print)1605-7422

Other

OtherOptical Interactions with Tissue and Cells XVIII
CountryUnited States
CitySan Jose, CA
Period07/1/2207/1/24

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Keywords

  • Balloon angioplasty
  • Birefringence
  • Collagen
  • Photo thermal reaction
  • Polarizing microscope
  • Rate process
  • Thermal denature

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Kaneko, K., Shimazaki, N., Gotoh, M., Nakatani, E., & Arai, T. (2007). Utility of birefringence changes due to collagen thermal denaturation rate process analysis: Vessel wall temperature estimation for new short term heating balloon angioplasty. In Optical Interactions with Tissue and Cells XVIII [64350F] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6435). https://doi.org/10.1117/12.699962