Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collage-induced arthritis

Aki Honda, Akio Ametani, Takashi Matsumoto, Amane Iwaya, Hiroshi Kano, Satoshi Hachimura, Kensuke Ohkawa, Shucihi Kaminogawa, Koji Suzuki, Eli E. Sercarz, Vipin Kumar

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

T cell responses directed toward TCR-derived peptides have been shown to be an important regulatory mechanism of protection against autoimmunity. Here, we show that a naturally induced TCR-directed immune response can delay the onset of collagen-induced arthritis (CIA), an animal model of autoimmune rheumatoid arthritis in humans. DBA/1 mice were pretreated with an immunodominant peptide, p245-270, from bovine type II collagen (bCII) and were subsequently immunized with whole bCII for the induction of arthritis. The results showed that preactivation of p245-270-reactive cells delayed the onset and reduced the severity of CIA, compared with animals in the control group. Interestingly, the serum antibody response to bCll and the bCII-specific cytokine were not affected under these conditions. This result indicates that the observed protection was neither directly due to a lower antibody response nor due to the immune deviation of the anti-bCII T cell response. Furthermore, immunization with p245-270, but not bCII, induced a strong response to the B5 peptide, an immunodominant region of the TCR Vβ8.2 (amino acids 76-101) that binds very strongly to I-Aq. These data suggest that at a critical phase in the loss of self-tolerance, an effective anti-TCR response, induced naturally, can regulate the pathogenic autoimmune response and thus may provide protection against autoimmunity.

Original languageEnglish
Pages (from-to)737-745
Number of pages9
JournalInternational Immunology
Volume16
Issue number5
DOIs
Publication statusPublished - 2004 May

Fingerprint

Collagen Type II
Autoimmunity
Arthritis
Vaccination
Experimental Arthritis
Peptides
Antibody Formation
T-Lymphocytes
Self Tolerance
Immunodominant Epitopes
Inbred DBA Mouse
Immunization
Rheumatoid Arthritis
Animal Models
Cytokines
Amino Acids
Control Groups
Serum

Keywords

  • Anti-TCR response
  • Collagen-induced arthritis
  • Immune regulation

ASJC Scopus subject areas

  • Immunology

Cite this

Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collage-induced arthritis. / Honda, Aki; Ametani, Akio; Matsumoto, Takashi; Iwaya, Amane; Kano, Hiroshi; Hachimura, Satoshi; Ohkawa, Kensuke; Kaminogawa, Shucihi; Suzuki, Koji; Sercarz, Eli E.; Kumar, Vipin.

In: International Immunology, Vol. 16, No. 5, 05.2004, p. 737-745.

Research output: Contribution to journalArticle

Honda, A, Ametani, A, Matsumoto, T, Iwaya, A, Kano, H, Hachimura, S, Ohkawa, K, Kaminogawa, S, Suzuki, K, Sercarz, EE & Kumar, V 2004, 'Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collage-induced arthritis', International Immunology, vol. 16, no. 5, pp. 737-745. https://doi.org/10.1093/intimm/dxh075
Honda, Aki ; Ametani, Akio ; Matsumoto, Takashi ; Iwaya, Amane ; Kano, Hiroshi ; Hachimura, Satoshi ; Ohkawa, Kensuke ; Kaminogawa, Shucihi ; Suzuki, Koji ; Sercarz, Eli E. ; Kumar, Vipin. / Vaccination with an immunodominant peptide of bovine type II collagen induces an anti-TCR response, and modulates the onset and severity of collage-induced arthritis. In: International Immunology. 2004 ; Vol. 16, No. 5. pp. 737-745.
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