Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

Yuya Yoshimoto, Takaaki Jyojima, Tsuyoshi Arita, Minoru Ueda, Masaya Imoto, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H+-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).

Original languageEnglish
Pages (from-to)3525-3528
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number24
DOIs
Publication statusPublished - 2002 Dec

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Vacuolar Proton-Translocating ATPases
Lactones
Bioactivity
Hydrogen
Hydrogen bonds
Cells
Apoptosis
Neoplasms
ErbB Receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

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abstract = "Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H+-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).",
author = "Yuya Yoshimoto and Takaaki Jyojima and Tsuyoshi Arita and Minoru Ueda and Masaya Imoto and Shuichi Matsumura and Kazunobu Toshima",
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T2 - Is the hydrogen bond network involving the lactone carbonyl, the hemiacetal hydroxy group, and the C-19 hydroxy group essential for the biological activity of the concanamycins?

AU - Yoshimoto, Yuya

AU - Jyojima, Takaaki

AU - Arita, Tsuyoshi

AU - Ueda, Minoru

AU - Imoto, Masaya

AU - Matsumura, Shuichi

AU - Toshima, Kazunobu

PY - 2002/12

Y1 - 2002/12

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