Valiable frequency characteristics multi-channel on-chip patch-clamp system using 0.18 um CMOS technology

Masahiro Kubo, Taro Kosaka, Takanori Miyawaki, Kota Ito, Nobuhiko Nakano

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Patch-clamp measurement system is one of the useful techniques in the field of Electrophysiology. This technique makes it possible to measure ion current and is expected to contribution of the treatment of neurological disease and elucidation of the neuronal activity. In this paper, we propose multi-channel patch-clamp measurement system. The system is composed of I-V converter, parasitic components compensation circuit, programmable gain amplifier, anti-aliasing filter, multiplexer, and serial to parallel converter. The current-to-voltage conversion rate of the whole system is a maximum 379 Gohm. The input referred current noise is achieved 1.86 pArms in simulation, 2.09 pArms in measurement. In order to fine tune the cutoff frequency of entire system, the variable capacitance is used for the filter. It is possible to eliminate the influence of variations between the channels in a multi-channel system. The system was fabricated using the 0.18um CMOS process. 8-channel system is implemented in a chip size of 2.5 mm times 5 mm.

    Original languageEnglish
    Title of host publication2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    ISBN (Electronic)9781509006298
    DOIs
    Publication statusPublished - 2017 Jan 18
    Event2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016 - Phuket, Thailand
    Duration: 2016 Oct 242016 Oct 27

    Other

    Other2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016
    CountryThailand
    CityPhuket
    Period16/10/2416/10/27

    Keywords

    • Anti-aliasing filter
    • Electrophysiology
    • I-V converter
    • Low-noise amplifier
    • Patch-clamp measurement
    • Programmable gain amplifier

    ASJC Scopus subject areas

    • Computer Networks and Communications
    • Signal Processing
    • Instrumentation

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  • Cite this

    Kubo, M., Kosaka, T., Miyawaki, T., Ito, K., & Nakano, N. (2017). Valiable frequency characteristics multi-channel on-chip patch-clamp system using 0.18 um CMOS technology. In 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016 [7824689] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISPACS.2016.7824689