Abstract
Patch-clamp measurement system is one of the useful techniques in the field of Electrophysiology. This technique makes it possible to measure ion current and is expected to contribution of the treatment of neurological disease and elucidation of the neuronal activity. In this paper, we propose multi-channel patch-clamp measurement system. The system is composed of I-V converter, parasitic components compensation circuit, programmable gain amplifier, anti-aliasing filter, multiplexer, and serial to parallel converter. The current-to-voltage conversion rate of the whole system is a maximum 379 Gohm. The input referred current noise is achieved 1.86 pArms in simulation, 2.09 pArms in measurement. In order to fine tune the cutoff frequency of entire system, the variable capacitance is used for the filter. It is possible to eliminate the influence of variations between the channels in a multi-channel system. The system was fabricated using the 0.18um CMOS process. 8-channel system is implemented in a chip size of 2.5 mm times 5 mm.
| Original language | English |
|---|---|
| Title of host publication | 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| ISBN (Electronic) | 9781509006298 |
| DOIs | |
| Publication status | Published - 2017 Jan 18 |
| Event | 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016 - Phuket, Thailand Duration: 2016 Oct 24 → 2016 Oct 27 |
Other
| Other | 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016 |
|---|---|
| Country | Thailand |
| City | Phuket |
| Period | 16/10/24 → 16/10/27 |
Fingerprint
Keywords
- Anti-aliasing filter
- Electrophysiology
- I-V converter
- Low-noise amplifier
- Patch-clamp measurement
- Programmable gain amplifier
ASJC Scopus subject areas
- Computer Networks and Communications
- Signal Processing
- Instrumentation
Cite this
Valiable frequency characteristics multi-channel on-chip patch-clamp system using 0.18 um CMOS technology. / Kubo, Masahiro; Kosaka, Taro; Miyawaki, Takanori; Ito, Kota; Nakano, Nobuhiko.
2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016. Institute of Electrical and Electronics Engineers Inc., 2017. 7824689.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Valiable frequency characteristics multi-channel on-chip patch-clamp system using 0.18 um CMOS technology
AU - Kubo, Masahiro
AU - Kosaka, Taro
AU - Miyawaki, Takanori
AU - Ito, Kota
AU - Nakano, Nobuhiko
PY - 2017/1/18
Y1 - 2017/1/18
N2 - Patch-clamp measurement system is one of the useful techniques in the field of Electrophysiology. This technique makes it possible to measure ion current and is expected to contribution of the treatment of neurological disease and elucidation of the neuronal activity. In this paper, we propose multi-channel patch-clamp measurement system. The system is composed of I-V converter, parasitic components compensation circuit, programmable gain amplifier, anti-aliasing filter, multiplexer, and serial to parallel converter. The current-to-voltage conversion rate of the whole system is a maximum 379 Gohm. The input referred current noise is achieved 1.86 pArms in simulation, 2.09 pArms in measurement. In order to fine tune the cutoff frequency of entire system, the variable capacitance is used for the filter. It is possible to eliminate the influence of variations between the channels in a multi-channel system. The system was fabricated using the 0.18um CMOS process. 8-channel system is implemented in a chip size of 2.5 mm times 5 mm.
AB - Patch-clamp measurement system is one of the useful techniques in the field of Electrophysiology. This technique makes it possible to measure ion current and is expected to contribution of the treatment of neurological disease and elucidation of the neuronal activity. In this paper, we propose multi-channel patch-clamp measurement system. The system is composed of I-V converter, parasitic components compensation circuit, programmable gain amplifier, anti-aliasing filter, multiplexer, and serial to parallel converter. The current-to-voltage conversion rate of the whole system is a maximum 379 Gohm. The input referred current noise is achieved 1.86 pArms in simulation, 2.09 pArms in measurement. In order to fine tune the cutoff frequency of entire system, the variable capacitance is used for the filter. It is possible to eliminate the influence of variations between the channels in a multi-channel system. The system was fabricated using the 0.18um CMOS process. 8-channel system is implemented in a chip size of 2.5 mm times 5 mm.
KW - Anti-aliasing filter
KW - Electrophysiology
KW - I-V converter
KW - Low-noise amplifier
KW - Patch-clamp measurement
KW - Programmable gain amplifier
UR - http://www.scopus.com/inward/record.url?scp=85015093073&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015093073&partnerID=8YFLogxK
U2 - 10.1109/ISPACS.2016.7824689
DO - 10.1109/ISPACS.2016.7824689
M3 - Conference contribution
BT - 2016 International Symposium on Intelligent Signal Processing and Communication Systems, ISPACS 2016
PB - Institute of Electrical and Electronics Engineers Inc.
ER -