TY - JOUR
T1 - Validation and reliability of the Timed Up and Go test for measuring objective functional impairment in patients with long-standing rheumatoid arthritis
T2 - a cross-sectional study
AU - Kojima, Toshihisa
AU - Ishikawa, Hajime
AU - Tanaka, Sakae
AU - Haga, Nobuhiko
AU - Nishida, Keiichiro
AU - Yukioka, Masao
AU - Hashimoto, Jun
AU - Miyahara, Hisaaki
AU - Niki, Yasuo
AU - Kimura, Tomoatsu
AU - Oda, Hiromi
AU - Asai, Shuji
AU - Funahashi, Koji
AU - Kojima, Masayo
AU - Ishiguro, Naoki
PY - 2018/10
Y1 - 2018/10
N2 - Aim: This study aimed to validate the Timed Up and Go test (TUG) for measuring objective functional impairment in patients with established rheumatoid arthritis (RA) based on a prospective observational cohort of RA patients undergoing joint surgery. Methods: We collected data on demographics, Health Assessment Questionnaire Disability Index (HAQ-DI), and associations between TUG and HAQ-DI and other patient-reported outcomes, including European Quality of life scale (EQ-5D) were determined. Cut-off values of TUG for HAQ remission (HAQ-DI ≤0.5), normal HAQ (HAQ-DI ≤0.25), and the absence of disability in each HAQ-DI category were also determined by age. Results: A total of 435 patients were enrolled and analyzed. Mean age was 64.2 years, mean disease duration was 17.1 years, mean HAQ-DI was 1.14, and mean TUG was 11.1 sec. TUG was significantly correlated with aging, EQ-5D, and HAQ-DI categories related to lower limb function (arising, walking, reach and activity). After adjusting for age and sex, mean TUG values were 9.0 sec (95% CI, 7.7–10.3) in patients with HAQ remission and 8.7 sec (7.4–10.4) in those with normal HAQ. By age, mean TUG values for HAQ remission were 7.2 sec (5.9–8.5) in young patients (≤61 years), 9.1 sec (7.6–10.5) in middle-aged patients (62–70 years) and 10.0 sec (5.7–14.2) in old patients (≥71 years). Conclusion: TUG was significantly associated with functional impairment and aging in patients with long-standing RA. Thus, TUG could be useful in setting treatment goals for joint surgery and rehabilitation in established RA patients.
AB - Aim: This study aimed to validate the Timed Up and Go test (TUG) for measuring objective functional impairment in patients with established rheumatoid arthritis (RA) based on a prospective observational cohort of RA patients undergoing joint surgery. Methods: We collected data on demographics, Health Assessment Questionnaire Disability Index (HAQ-DI), and associations between TUG and HAQ-DI and other patient-reported outcomes, including European Quality of life scale (EQ-5D) were determined. Cut-off values of TUG for HAQ remission (HAQ-DI ≤0.5), normal HAQ (HAQ-DI ≤0.25), and the absence of disability in each HAQ-DI category were also determined by age. Results: A total of 435 patients were enrolled and analyzed. Mean age was 64.2 years, mean disease duration was 17.1 years, mean HAQ-DI was 1.14, and mean TUG was 11.1 sec. TUG was significantly correlated with aging, EQ-5D, and HAQ-DI categories related to lower limb function (arising, walking, reach and activity). After adjusting for age and sex, mean TUG values were 9.0 sec (95% CI, 7.7–10.3) in patients with HAQ remission and 8.7 sec (7.4–10.4) in those with normal HAQ. By age, mean TUG values for HAQ remission were 7.2 sec (5.9–8.5) in young patients (≤61 years), 9.1 sec (7.6–10.5) in middle-aged patients (62–70 years) and 10.0 sec (5.7–14.2) in old patients (≥71 years). Conclusion: TUG was significantly associated with functional impairment and aging in patients with long-standing RA. Thus, TUG could be useful in setting treatment goals for joint surgery and rehabilitation in established RA patients.
KW - Timed Up and Go test
KW - outcome measure
KW - physical function
KW - rehabilitation
KW - rheumatoid arthritis
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U2 - 10.1111/1756-185X.13237
DO - 10.1111/1756-185X.13237
M3 - Article
C2 - 29210204
AN - SCOPUS:85037332688
VL - 21
SP - 1793
EP - 1800
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
SN - 1756-1841
IS - 10
ER -