Validation of serological models for staging and prognostication of HCC in patients from a Japanese nationwide survey

The Liver Cancer Study Group Of Japan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Two serology-based scoring models for prognostication of patients with hepatocellular carcinoma (HCC), the BALAD and BALAD-2 models, were applied to a Japanese cohort of a nationwide follow-up survey of HCC. The ability of these models to predict the progression of HCC and the deterioration of liver function and to assess prognosis was evaluated. Methods: BALAD and BALAD-2 scores were calculated in 24,029 patients from a cohort of Japanese nationwide survey based on the serum levels of five markers (bilirubin, albumin, lens culinaris agglutinin-reactive alpha-fetoprotein, alpha-fetoprotein, and des-gamma-carboxy prothrombin) measured at the time of HCC diagnosis. The associations of these scores with the progression of HCC and liver function and with survival rates were analyzed. Results: There were good correlations between BALAD and BALAD-2 scores and the progression of HCC and Child–Pugh class. Both scores accurately categorized patients into risk groups with different survival rates. BALAD-2 showed superior discrimination of patient survival compared with the original BALAD. Conclusions: Serology-based scoring models for prognostication, especially the BALAD-2 model, were useful for staging and prognostication of survival in a cohort of Japanese patients with HCC from a nationwide survey.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Gastroenterology
DOIs
Publication statusAccepted/In press - 2017 Feb 21

Keywords

  • Hepatocellular carcinoma
  • Liver function
  • Prognosis
  • Serological markers
  • Staging
  • Tumor progression

ASJC Scopus subject areas

  • Gastroenterology

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