Validation of the Accuracy of Self-Reported ABO Blood Types in the Japan Nurses’ Health Study

Lobna Alkebsi, Hiroshi Ohnishi, Junko Nakajima-Shimada, Yoko Onizuka, Yuki Ideno, Yasunori Sato, Kunihiko Hayashi

Research output: Contribution to journalArticle

Abstract

Background: The associations between ABO blood type and risk of diseases including cancer have been reported from epidemiological studies. Self-reporting is one of the most widely used methods of collecting the ABO blood type information. Verifying the accuracy of self-reporting is important to consider measurement errors. We aimed to conduct validation of self-reported ABO blood types in the Japan Nurses’ Health Study (JNHS), which is a large prospective cohort study. Methods: The concordance rate between self-reported and serologically or genetically inferred ABO blood groups was investigated for a subsample of 41 subjects from the Gunma Nurses’ Health Study, which was a pilot cohort study that preceded the JNHS. The presence of antibodies to A or B antigens in serum (serological test) and allele types of the ABO gene (genotyping test) were determined by using frozen blood samples that were preserved for approximately 7 years. ABO blood types were determined from these tests and compared with self-reported data. Results: All of the nurses reported that their ABO blood groups were concordant with those determined by a serological and/or genotyping test. Self-reported ABO blood types of 35 of 38 (92.1%) participants were consistent with the results from serological typing, while the answers of three participants were not. In these three participants, ABO genotypes that were inferred from genotyping of three single nucleotide polymorphisms in ABO loci perfectly matched with their self-reported ABO types, and all of these were O-type. Conclusions: Japanese health professionals report their blood type with a high degree of accuracy. Special attention should be paid to the O-type group in serological analysis of blood samples that have been preserved for several years in longitudinal studies.

Original languageEnglish
Pages (from-to)789-793
Number of pages5
JournalAsian Pacific journal of cancer prevention : APJCP
Volume20
Issue number3
DOIs
Publication statusPublished - 2019 Mar 26

Fingerprint

Japan
Nurses
Health
Blood Group Antigens
Cohort Studies
Hematologic Diseases
Serologic Tests
Single Nucleotide Polymorphism
Longitudinal Studies
Epidemiologic Studies
Alleles
Genotype
Prospective Studies
Antigens
Antibodies
Serum
Genes
Neoplasms

Keywords

  • ABO blood-group system
  • blood preservation
  • genotyping techniques
  • self report
  • serological tests

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Validation of the Accuracy of Self-Reported ABO Blood Types in the Japan Nurses’ Health Study. / Alkebsi, Lobna; Ohnishi, Hiroshi; Nakajima-Shimada, Junko; Onizuka, Yoko; Ideno, Yuki; Sato, Yasunori; Hayashi, Kunihiko.

In: Asian Pacific journal of cancer prevention : APJCP, Vol. 20, No. 3, 26.03.2019, p. 789-793.

Research output: Contribution to journalArticle

Alkebsi, L, Ohnishi, H, Nakajima-Shimada, J, Onizuka, Y, Ideno, Y, Sato, Y & Hayashi, K 2019, 'Validation of the Accuracy of Self-Reported ABO Blood Types in the Japan Nurses’ Health Study', Asian Pacific journal of cancer prevention : APJCP, vol. 20, no. 3, pp. 789-793. https://doi.org/10.31557/apjcp.2019.20.3.789
Alkebsi, Lobna ; Ohnishi, Hiroshi ; Nakajima-Shimada, Junko ; Onizuka, Yoko ; Ideno, Yuki ; Sato, Yasunori ; Hayashi, Kunihiko. / Validation of the Accuracy of Self-Reported ABO Blood Types in the Japan Nurses’ Health Study. In: Asian Pacific journal of cancer prevention : APJCP. 2019 ; Vol. 20, No. 3. pp. 789-793.
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