Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis

Toshihiko Mayumi, Kazuo Inui, Iruru Maetani, Masamichi Yokoe, Teruo Sakamoto, Masahiro Yoshida, Shigeru Ko, Koichi Hirata, Tadahiro Takada

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: A simple urinary trypsinogen-2 test was evaluated for the diagnosis of acute pancreatitis. Methods: This prospective multicenter study enrolled consecutive patients with acute abdominal pain who presented to the emergency department or who were hospitalized at 1 of 21 medical institutions in Japan. Patients were tested with urinary trypsinogen-2 dipstick test and a quantitative trypsinogen-2 assay, and these values were compared with serum amylase and lipase findings. Results: A total of 412 patients were enrolled. The trypsinogen-2 dipstick test was positive in 107 of 156 patients with acute pancreatitis (sensitivity, 68.6%) and in 33 of 256 patients with nonpancreatic abdominal pain (specificity, 87.1%). The sensitivity for the diagnosis of pancreatitis caused by alcohol and gallstones by the dipstick test was 72.2% and 81.8%, respectively, which was much higher than those associated with amylase testing. There are several degrees of positivity within the urinary trypsinogen-2 dipstick test. Modification of the cutoff point such that positive (+) and most positive (++) results were interpreted as a positive result, the specificity and positive likelihood ratio increased to 92.2% and 7.63, respectively. Conclusions: This simple, rapid, easy, and noninvasive urinary trypsinogen-2 test can diagnose or rule out most cases of acute pancreatitis.

Original languageEnglish
Pages (from-to)869-875
Number of pages7
JournalPancreas
Volume41
Issue number6
DOIs
Publication statusPublished - 2012 Aug 1

    Fingerprint

Keywords

  • acute pancreatitis
  • diagnosis
  • urinary trypsinogen-2 assay
  • urinary trypsinogen-2 dipstick test

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Mayumi, T., Inui, K., Maetani, I., Yokoe, M., Sakamoto, T., Yoshida, M., Ko, S., Hirata, K., & Takada, T. (2012). Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis. Pancreas, 41(6), 869-875. https://doi.org/10.1097/MPA.0b013e3182480ab7