Values of cardio-ankle vascular index (CAVI) between amami islands and kagoshima mainland among health checkup examinees

Kazuyo Kuwabara, Hideshi Niimura, Takuro Kubozono, Akihiko Nakamura, Masaya Tatebo, Shin Ogawa, Noriko Tsunematsu, Shirabe Chiba, Toshifumi Matsushita, Ken Kusano, Masaaki Miyata, Toshiro Takezaki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Aim: To investigate the prevalence and geographical variation of high arterial stiffness in groups from the Amami islands (Amami) and Kagoshima mainland (mainland), Japan, using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 4,523 health checkup examinees from Amami and 440 examinees from the mainland, with an age range of 40-69 years. The frequency of high arterial stiffness (CAVI ≥9.0) was geographically compared between the regions, and both mean CAVI values were compared with those of the healthy Japanese population with less risk factors for coronary artery disease. Clinical, lifestyle, and regional factors for increased CAVI values were estimated by the multiple linear regression model. Results: The frequency of high arterial stiffness on Amami was significantly lower than on the mainland. Mean CAVI values on Amami were similar in males and lower in females than in the healthy Japanese population, but those on the mainland were higher for both sexes. Age, systolic blood pressure, triglycerides, fasting blood glucose, and a history of hypertension and diabetes mellitus were positively related to increased CAVI values on Amami. The regional factor of Amami, compared with the mainland, was negatively related to increased CAVI values in both sexes after adjusting for traditional cardiovascular risk factors. Conclusion: CAVI values in Amami residents were significantly lower than in mainland residents, suggesting that environmental or genetic factors might have improved arterial stiffness in the Amami population.

Original languageEnglish
Pages (from-to)69-80
Number of pages12
JournalJournal of Atherosclerosis and Thrombosis
Volume19
Issue number1
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Islands
Ankle
Blood Vessels
Vascular Stiffness
Stiffness
Health
Blood pressure
Linear Models
Medical problems
Linear regression
Blood Glucose
Population
Blood Pressure
Triglycerides
Life Style
Coronary Artery Disease
Fasting
Diabetes Mellitus
Japan
Biomarkers

Keywords

  • Arterial stiffness
  • Cardio-ankle vascular index
  • Geographical variation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

Values of cardio-ankle vascular index (CAVI) between amami islands and kagoshima mainland among health checkup examinees. / Kuwabara, Kazuyo; Niimura, Hideshi; Kubozono, Takuro; Nakamura, Akihiko; Tatebo, Masaya; Ogawa, Shin; Tsunematsu, Noriko; Chiba, Shirabe; Matsushita, Toshifumi; Kusano, Ken; Miyata, Masaaki; Takezaki, Toshiro.

In: Journal of Atherosclerosis and Thrombosis, Vol. 19, No. 1, 2012, p. 69-80.

Research output: Contribution to journalArticle

Kuwabara, K, Niimura, H, Kubozono, T, Nakamura, A, Tatebo, M, Ogawa, S, Tsunematsu, N, Chiba, S, Matsushita, T, Kusano, K, Miyata, M & Takezaki, T 2012, 'Values of cardio-ankle vascular index (CAVI) between amami islands and kagoshima mainland among health checkup examinees', Journal of Atherosclerosis and Thrombosis, vol. 19, no. 1, pp. 69-80. https://doi.org/10.5551/jat.6627
Kuwabara, Kazuyo ; Niimura, Hideshi ; Kubozono, Takuro ; Nakamura, Akihiko ; Tatebo, Masaya ; Ogawa, Shin ; Tsunematsu, Noriko ; Chiba, Shirabe ; Matsushita, Toshifumi ; Kusano, Ken ; Miyata, Masaaki ; Takezaki, Toshiro. / Values of cardio-ankle vascular index (CAVI) between amami islands and kagoshima mainland among health checkup examinees. In: Journal of Atherosclerosis and Thrombosis. 2012 ; Vol. 19, No. 1. pp. 69-80.
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AU - Tatebo, Masaya

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