Variability in drug response caused by the genetic polymorphisms of receptors

Yusuke Tanigawara, Osamu Iketani, Yasuko Yamayoshi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A greater deal of attention has been given to the genetic polymorphism of receptors and related variability in drug response. In recent years, studies on pharmacogenomics accomplished remarkable progress in this issue. These studies include, the relationships between beta 2-adrenegic receptor polymorphism and the pharmacological effect of blonchodilator, dopamine D2 or 5-HT2 receptor polymorphism and response to antipsychotic medication, vitamin D receptor variants and the active vitamin D therapy, PPAR gamma and the insulin resistance treatment and so on. However, some of them are still controversial, and it requires further investigation to apply these studies to the actual therapy.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume60
Issue number1
Publication statusPublished - 2002

Fingerprint

Genetic Polymorphisms
Calcitriol Receptors
PPAR gamma
Vitamin D
Pharmaceutical Preparations
Antipsychotic Agents
Insulin Resistance
Dopamine
Pharmacology
Therapeutics
Pharmacogenomic Testing

Cite this

Variability in drug response caused by the genetic polymorphisms of receptors. / Tanigawara, Yusuke; Iketani, Osamu; Yamayoshi, Yasuko.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 60, No. 1, 2002, p. 51-57.

Research output: Contribution to journalArticle

@article{8e7284cfc8044c1ca36b07724c77cfee,
title = "Variability in drug response caused by the genetic polymorphisms of receptors",
abstract = "A greater deal of attention has been given to the genetic polymorphism of receptors and related variability in drug response. In recent years, studies on pharmacogenomics accomplished remarkable progress in this issue. These studies include, the relationships between beta 2-adrenegic receptor polymorphism and the pharmacological effect of blonchodilator, dopamine D2 or 5-HT2 receptor polymorphism and response to antipsychotic medication, vitamin D receptor variants and the active vitamin D therapy, PPAR gamma and the insulin resistance treatment and so on. However, some of them are still controversial, and it requires further investigation to apply these studies to the actual therapy.",
author = "Yusuke Tanigawara and Osamu Iketani and Yasuko Yamayoshi",
year = "2002",
language = "English",
volume = "60",
pages = "51--57",
journal = "Nihon rinsho. Japanese journal of clinical medicine",
issn = "0047-1852",
publisher = "Nipponrinsho Co., Inc.",
number = "1",

}

TY - JOUR

T1 - Variability in drug response caused by the genetic polymorphisms of receptors

AU - Tanigawara, Yusuke

AU - Iketani, Osamu

AU - Yamayoshi, Yasuko

PY - 2002

Y1 - 2002

N2 - A greater deal of attention has been given to the genetic polymorphism of receptors and related variability in drug response. In recent years, studies on pharmacogenomics accomplished remarkable progress in this issue. These studies include, the relationships between beta 2-adrenegic receptor polymorphism and the pharmacological effect of blonchodilator, dopamine D2 or 5-HT2 receptor polymorphism and response to antipsychotic medication, vitamin D receptor variants and the active vitamin D therapy, PPAR gamma and the insulin resistance treatment and so on. However, some of them are still controversial, and it requires further investigation to apply these studies to the actual therapy.

AB - A greater deal of attention has been given to the genetic polymorphism of receptors and related variability in drug response. In recent years, studies on pharmacogenomics accomplished remarkable progress in this issue. These studies include, the relationships between beta 2-adrenegic receptor polymorphism and the pharmacological effect of blonchodilator, dopamine D2 or 5-HT2 receptor polymorphism and response to antipsychotic medication, vitamin D receptor variants and the active vitamin D therapy, PPAR gamma and the insulin resistance treatment and so on. However, some of them are still controversial, and it requires further investigation to apply these studies to the actual therapy.

UR - http://www.scopus.com/inward/record.url?scp=0036371201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036371201&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 51

EP - 57

JO - Nihon rinsho. Japanese journal of clinical medicine

JF - Nihon rinsho. Japanese journal of clinical medicine

SN - 0047-1852

IS - 1

ER -