Variability in drug response caused by the genetic polymorphisms of receptors

Yusuke Tanigawara, Osamu Iketani, Yasuko Yamayoshi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

A greater deal of attention has been given to the genetic polymorphism of receptors and related variability in drug response. In recent years, studies on pharmacogenomics accomplished remarkable progress in this issue. These studies include, the relationships between beta 2-adrenegic receptor polymorphism and the pharmacological effect of blonchodilator, dopamine D2 or 5-HT2 receptor polymorphism and response to antipsychotic medication, vitamin D receptor variants and the active vitamin D therapy, PPAR gamma and the insulin resistance treatment and so on. However, some of them are still controversial, and it requires further investigation to apply these studies to the actual therapy.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume60
Issue number1
Publication statusPublished - 2002 Jan

ASJC Scopus subject areas

  • Medicine(all)

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