Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat

E. Nakashima, D. T W Lau, L. Z. Benet

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The availability of glyceryl trinitrate (GTN) and the differential formation of dinitrate metabolites (GDNs) in various organs as a function of routes of administration were investigated in the rat. GTN was infused at 2.0 μg/min via the left femoral vein (LFV), left external jugular vein (LJV), left femoral artery (LFA), and hepatic portal vein (HPV). Blood concentrations of GTN and GDNs were measured in femoral arterial samples. Different infusions yielded GTN steady-state concentrations in the following rank order: LJV ≥ LFV > LFA ≥ HPV. Furthermore, the GDN formation ratios (1,2-GDN/1,3-GDN) are different: LFV ≥ LJV > LFA > HPV. The availabilities of GTN through the leg, vein, and liver were derived. GTN is significantly extracted and metabolized in these organs, and the leg and the vein prefer 1,2-GDN formation, while the liver forms 1,3-GDN predominantly.

Original languageEnglish
Pages (from-to)877-882
Number of pages6
JournalPharmaceutical Research
Volume8
Issue number7
Publication statusPublished - 1991
Externally publishedYes

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Nitroglycerin
Blood Vessels
Rats
Hepatic Veins
Femoral Vein
Jugular Veins
Femoral Artery
Portal Vein
Liver
Veins
Leg
Availability
Metabolites
Thigh
dinitroglycerol
Blood

ASJC Scopus subject areas

  • Chemistry(all)
  • Pharmaceutical Science
  • Pharmacology

Cite this

Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat. / Nakashima, E.; Lau, D. T W; Benet, L. Z.

In: Pharmaceutical Research, Vol. 8, No. 7, 1991, p. 877-882.

Research output: Contribution to journalArticle

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