Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome

Toshihide Kawai, Maggie C Y Ng, M. Geoffrey Hayes, Issei Yoshiuchi, Takafumi Tsuchiya, Heather Robertson, Nancy J. Cox, Kenneth S. Polonsky, Graeme I. Bell, David A. Ehrmann

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is characterized by chronic anovulation, hyperandrogenism, obesity and a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS. We typed six single nucleotide polymorphisms (haplotype tagging and/or previously associated with obesity or related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women (185 with PCOS and 120 without PCOS). None of the variants was associated with PCOS (P < 0.05). However, the variant rs1052700*A was associated with increased risk for glucose intolerance (impaired glucose tolerance or T2DM) in both non-PCOS (OR = 1.75 [1.02-3.01], P = 0.044) and PCOS subjects (OR = 1.67 [1.08-2.59], P = 0.022). It was also associated with increased LDL (P = 0.007) and total cholesterol levels (P = 0.042). These results suggest that genetic variation in PLIN may affect glucose and lipid metabolism in women both with and without PCOS.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume86
Issue number3
DOIs
Publication statusPublished - 2009 Dec
Externally publishedYes

Fingerprint

Polycystic Ovary Syndrome
Lipid Metabolism
Glucose
Genes
Obesity
Glucose Intolerance
Type 2 Diabetes Mellitus
Anovulation
Hyperandrogenism
Perilipin-1
Haplotypes
Single Nucleotide Polymorphism
Ovary
Cholesterol

Keywords

  • Glucose
  • Lipid
  • Perilipin
  • Polycystic ovary syndrome (PCOS)
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. / Kawai, Toshihide; Ng, Maggie C Y; Hayes, M. Geoffrey; Yoshiuchi, Issei; Tsuchiya, Takafumi; Robertson, Heather; Cox, Nancy J.; Polonsky, Kenneth S.; Bell, Graeme I.; Ehrmann, David A.

In: Diabetes Research and Clinical Practice, Vol. 86, No. 3, 12.2009, p. 186-192.

Research output: Contribution to journalArticle

Kawai, T, Ng, MCY, Hayes, MG, Yoshiuchi, I, Tsuchiya, T, Robertson, H, Cox, NJ, Polonsky, KS, Bell, GI & Ehrmann, DA 2009, 'Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome', Diabetes Research and Clinical Practice, vol. 86, no. 3, pp. 186-192. https://doi.org/10.1016/j.diabres.2009.09.002
Kawai, Toshihide ; Ng, Maggie C Y ; Hayes, M. Geoffrey ; Yoshiuchi, Issei ; Tsuchiya, Takafumi ; Robertson, Heather ; Cox, Nancy J. ; Polonsky, Kenneth S. ; Bell, Graeme I. ; Ehrmann, David A. / Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. In: Diabetes Research and Clinical Practice. 2009 ; Vol. 86, No. 3. pp. 186-192.
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