Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome

Toshihide Kawai, Maggie C.Y. Ng, M. Geoffrey Hayes, Issei Yoshiuchi, Takafumi Tsuchiya, Heather Robertson, Nancy J. Cox, Kenneth S. Polonsky, Graeme I. Bell, David A. Ehrmann

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13 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women. It is characterized by chronic anovulation, hyperandrogenism, obesity and a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an important role in the etiology of PCOS, we sought to determine if variants in the perilipin gene (PLIN), a gene previously implicated in the development of obesity, were also associated with PCOS. We typed six single nucleotide polymorphisms (haplotype tagging and/or previously associated with obesity or related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women (185 with PCOS and 120 without PCOS). None of the variants was associated with PCOS (P < 0.05). However, the variant rs1052700*A was associated with increased risk for glucose intolerance (impaired glucose tolerance or T2DM) in both non-PCOS (OR = 1.75 [1.02-3.01], P = 0.044) and PCOS subjects (OR = 1.67 [1.08-2.59], P = 0.022). It was also associated with increased LDL (P = 0.007) and total cholesterol levels (P = 0.042). These results suggest that genetic variation in PLIN may affect glucose and lipid metabolism in women both with and without PCOS.

Original languageEnglish
Pages (from-to)186-192
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume86
Issue number3
DOIs
Publication statusPublished - 2009 Dec 1

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Keywords

  • Glucose
  • Lipid
  • Perilipin
  • Polycystic ovary syndrome (PCOS)
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kawai, T., Ng, M. C. Y., Hayes, M. G., Yoshiuchi, I., Tsuchiya, T., Robertson, H., Cox, N. J., Polonsky, K. S., Bell, G. I., & Ehrmann, D. A. (2009). Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in non-Hispanic white women with and without polycystic ovary syndrome. Diabetes Research and Clinical Practice, 86(3), 186-192. https://doi.org/10.1016/j.diabres.2009.09.002