Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions

E. Kunieda, H. M. Deloar, N. Kishitani, T. Fujisaki, T. Kawase, S. Seki, Y. Oku, A. Kubo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To clarify the effects of respiratory condition on dose calculation for stereotactic radiotherapy of small lung tumors. Methods and materials: Computed tomography (CT) data were obtained for nine tumors (diameter, 2.1-3.6 cm; mean, 2.7 cm) during the stable state, deep expiration, and deep inspiration breath-hold states. Rotational Irradiation with 3 non-coplanar arcs (Rotational Irradiation) and static irradiation with 18 non-coplanar ports (Static Irradiation) using 6-MV photons were evaluated using Fast Fourier Transform (FFT) convolution and Multigrid (MG) superposition algorithms. Dose-volume histograms (DVHs), mean path-length (PL) and mean effective path-length (EPL) were calculated. Results: Although the PL was larger for the inspiration state than for the stable state and the expiration state, the EPL was 0.4-0.5 cm smaller in the inspiration state than in the expiration state (p = 0.01 for Rotational Irradiation; p = 0.03 for Static Irradiation). The isocenter dose obtained by the FFT convolution algorithm was 7-12% higher than that obtained with the MG superposition algorithm. A leftward shift of the DVH obtained by MG superposition was noted for the inspiration state compared with the expiration state. Conclusions: The choice of the proper algorithm is important to accounting for changes in respiration state. Differences in isocenter dose were not large among the respiratory states analyzed. EPL was a little shorter for inspiration than for expiration, although there were larger and reverse trends in path length. A leftward shift of the DVH obtained for the inspiration state when MG superposition was used.

Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalPhysica Medica
Volume24
Issue number4
DOIs
Publication statusPublished - 2008 Dec

Fingerprint

inspiration
expiration
Tumor Burden
lungs
radiation therapy
Radiotherapy
tumors
dosage
Lung
irradiation
Fourier Analysis
histograms
convolution integrals
Photons
Neoplasms
Respiration
shift
Tomography
respiration
arcs

Keywords

  • Electron density
  • Lung tumor
  • Path-length
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions. / Kunieda, E.; Deloar, H. M.; Kishitani, N.; Fujisaki, T.; Kawase, T.; Seki, S.; Oku, Y.; Kubo, A.

In: Physica Medica, Vol. 24, No. 4, 12.2008, p. 204-211.

Research output: Contribution to journalArticle

Kunieda, E, Deloar, HM, Kishitani, N, Fujisaki, T, Kawase, T, Seki, S, Oku, Y & Kubo, A 2008, 'Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions', Physica Medica, vol. 24, no. 4, pp. 204-211. https://doi.org/10.1016/j.ejmp.2008.02.002
Kunieda, E. ; Deloar, H. M. ; Kishitani, N. ; Fujisaki, T. ; Kawase, T. ; Seki, S. ; Oku, Y. ; Kubo, A. / Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions. In: Physica Medica. 2008 ; Vol. 24, No. 4. pp. 204-211.
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abstract = "Purpose: To clarify the effects of respiratory condition on dose calculation for stereotactic radiotherapy of small lung tumors. Methods and materials: Computed tomography (CT) data were obtained for nine tumors (diameter, 2.1-3.6 cm; mean, 2.7 cm) during the stable state, deep expiration, and deep inspiration breath-hold states. Rotational Irradiation with 3 non-coplanar arcs (Rotational Irradiation) and static irradiation with 18 non-coplanar ports (Static Irradiation) using 6-MV photons were evaluated using Fast Fourier Transform (FFT) convolution and Multigrid (MG) superposition algorithms. Dose-volume histograms (DVHs), mean path-length (PL) and mean effective path-length (EPL) were calculated. Results: Although the PL was larger for the inspiration state than for the stable state and the expiration state, the EPL was 0.4-0.5 cm smaller in the inspiration state than in the expiration state (p = 0.01 for Rotational Irradiation; p = 0.03 for Static Irradiation). The isocenter dose obtained by the FFT convolution algorithm was 7-12{\%} higher than that obtained with the MG superposition algorithm. A leftward shift of the DVH obtained by MG superposition was noted for the inspiration state compared with the expiration state. Conclusions: The choice of the proper algorithm is important to accounting for changes in respiration state. Differences in isocenter dose were not large among the respiratory states analyzed. EPL was a little shorter for inspiration than for expiration, although there were larger and reverse trends in path length. A leftward shift of the DVH obtained for the inspiration state when MG superposition was used.",
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T1 - Variation of dose distribution of stereotactic radiotherapy for small-volume lung tumors under different respiratory conditions

AU - Kunieda, E.

AU - Deloar, H. M.

AU - Kishitani, N.

AU - Fujisaki, T.

AU - Kawase, T.

AU - Seki, S.

AU - Oku, Y.

AU - Kubo, A.

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N2 - Purpose: To clarify the effects of respiratory condition on dose calculation for stereotactic radiotherapy of small lung tumors. Methods and materials: Computed tomography (CT) data were obtained for nine tumors (diameter, 2.1-3.6 cm; mean, 2.7 cm) during the stable state, deep expiration, and deep inspiration breath-hold states. Rotational Irradiation with 3 non-coplanar arcs (Rotational Irradiation) and static irradiation with 18 non-coplanar ports (Static Irradiation) using 6-MV photons were evaluated using Fast Fourier Transform (FFT) convolution and Multigrid (MG) superposition algorithms. Dose-volume histograms (DVHs), mean path-length (PL) and mean effective path-length (EPL) were calculated. Results: Although the PL was larger for the inspiration state than for the stable state and the expiration state, the EPL was 0.4-0.5 cm smaller in the inspiration state than in the expiration state (p = 0.01 for Rotational Irradiation; p = 0.03 for Static Irradiation). The isocenter dose obtained by the FFT convolution algorithm was 7-12% higher than that obtained with the MG superposition algorithm. A leftward shift of the DVH obtained by MG superposition was noted for the inspiration state compared with the expiration state. Conclusions: The choice of the proper algorithm is important to accounting for changes in respiration state. Differences in isocenter dose were not large among the respiratory states analyzed. EPL was a little shorter for inspiration than for expiration, although there were larger and reverse trends in path length. A leftward shift of the DVH obtained for the inspiration state when MG superposition was used.

AB - Purpose: To clarify the effects of respiratory condition on dose calculation for stereotactic radiotherapy of small lung tumors. Methods and materials: Computed tomography (CT) data were obtained for nine tumors (diameter, 2.1-3.6 cm; mean, 2.7 cm) during the stable state, deep expiration, and deep inspiration breath-hold states. Rotational Irradiation with 3 non-coplanar arcs (Rotational Irradiation) and static irradiation with 18 non-coplanar ports (Static Irradiation) using 6-MV photons were evaluated using Fast Fourier Transform (FFT) convolution and Multigrid (MG) superposition algorithms. Dose-volume histograms (DVHs), mean path-length (PL) and mean effective path-length (EPL) were calculated. Results: Although the PL was larger for the inspiration state than for the stable state and the expiration state, the EPL was 0.4-0.5 cm smaller in the inspiration state than in the expiration state (p = 0.01 for Rotational Irradiation; p = 0.03 for Static Irradiation). The isocenter dose obtained by the FFT convolution algorithm was 7-12% higher than that obtained with the MG superposition algorithm. A leftward shift of the DVH obtained by MG superposition was noted for the inspiration state compared with the expiration state. Conclusions: The choice of the proper algorithm is important to accounting for changes in respiration state. Differences in isocenter dose were not large among the respiratory states analyzed. EPL was a little shorter for inspiration than for expiration, although there were larger and reverse trends in path length. A leftward shift of the DVH obtained for the inspiration state when MG superposition was used.

KW - Electron density

KW - Lung tumor

KW - Path-length

KW - Stereotactic radiotherapy

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