TY - JOUR
T1 - Variegated RHOA mutations in human cancers
AU - Kataoka, Keisuke
AU - Ogawa, Seishi
N1 - Publisher Copyright:
© 2016 ISEH - International Society for Experimental Hematology
PY - 2016/12/1
Y1 - 2016/12/1
N2 - RHOA is one of the most extensively investigated members of the Rho GTPase family of proteins and has long been implicated in malignant transformation as well as tumor invasion and metastasis. Recently, revolutionized sequencing platforms have revealed frequent RHOA mutations in a wide variety of human cancers, including angio-immunoblastic T-cell lymphoma, adult T-cell leukemia/lymphoma, germinal center B-cell lymphoma, diffuse-type gastric cancer, and other solid tumors. With their discrete positional distributions and types of amino acid substitution depending on cancer type, different RHOA mutations seem to have unique functional and biological properties. However, their impact on the development of different types of tumors remains controversial. Here, we present an overview of the current understanding of RHOA mutations in human cancers and highlight the unanticipated complexity of their genetic and biological properties.
AB - RHOA is one of the most extensively investigated members of the Rho GTPase family of proteins and has long been implicated in malignant transformation as well as tumor invasion and metastasis. Recently, revolutionized sequencing platforms have revealed frequent RHOA mutations in a wide variety of human cancers, including angio-immunoblastic T-cell lymphoma, adult T-cell leukemia/lymphoma, germinal center B-cell lymphoma, diffuse-type gastric cancer, and other solid tumors. With their discrete positional distributions and types of amino acid substitution depending on cancer type, different RHOA mutations seem to have unique functional and biological properties. However, their impact on the development of different types of tumors remains controversial. Here, we present an overview of the current understanding of RHOA mutations in human cancers and highlight the unanticipated complexity of their genetic and biological properties.
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U2 - 10.1016/j.exphem.2016.09.002
DO - 10.1016/j.exphem.2016.09.002
M3 - Review article
C2 - 27693615
AN - SCOPUS:84994890197
VL - 44
SP - 1123
EP - 1129
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 12
ER -