Various facets of vertebrate cilia: Motility, signaling, and role in adult neurogenesis

Shihhui Huang; Yuki Hirota; Kazunobu Sawamoto

doi:10.2183/pjab.85.324

Various facets of vertebrate cilia: Motility, signaling, and role in adult neurogenesis

Shihhui Huang, Yuki Hirota, Kazunobu Sawamoto

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.

Original language	English
Pages (from-to)	324-336
Number of pages	13
Journal	Proceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume	85
Issue number	8
DOIs	https://doi.org/10.2183/pjab.85.324
Publication status	Published - 2009 Oct
Externally published	Yes

Keywords

Cilia
Ciliopathy
Morphogenesis

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Physics and Astronomy(all)

Access to Document

10.2183/pjab.85.324

Cite this

@article{fb6b4f703ec44743be89e06672e1109b,

title = "Various facets of vertebrate cilia: Motility, signaling, and role in adult neurogenesis",

abstract = "Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.",

keywords = "Cilia, Ciliopathy, Morphogenesis",

author = "Shihhui Huang and Yuki Hirota and Kazunobu Sawamoto",

year = "2009",

month = oct,

doi = "10.2183/pjab.85.324",

language = "English",

volume = "85",

pages = "324--336",

journal = "Proceedings of the Japan Academy Series B: Physical and Biological Sciences",

issn = "0386-2208",

publisher = "Japan Academy",

number = "8",

}

TY - JOUR

T1 - Various facets of vertebrate cilia

T2 - Motility, signaling, and role in adult neurogenesis

AU - Huang, Shihhui

AU - Hirota, Yuki

AU - Sawamoto, Kazunobu

PY - 2009/10

Y1 - 2009/10

N2 - Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.

AB - Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.

KW - Cilia

KW - Ciliopathy

KW - Morphogenesis

UR - http://www.scopus.com/inward/record.url?scp=74949092032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74949092032&partnerID=8YFLogxK

U2 - 10.2183/pjab.85.324

DO - 10.2183/pjab.85.324

M3 - Review article

C2 - 19838012

AN - SCOPUS:74949092032

SN - 0386-2208

VL - 85

SP - 324

EP - 336

JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences

JF - Proceedings of the Japan Academy Series B: Physical and Biological Sciences

IS - 8

ER -

Various facets of vertebrate cilia: Motility, signaling, and role in adult neurogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this