Various facets of vertebrate cilia: Motility, signaling, and role in adult neurogenesis

Shihhui Huang, Yuki Hirota, Kazunobu Sawamoto

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Cilia are microtubule-based cellular organelles that are widely distributed in vertebrate tissues. They were first observed hundreds of years ago. Recent studies indicate that this small organelle plays important roles in numerous physiological phenomena, including tissue morphogenesis, signal transduction, determination of left-right asymmetry during development, and adult neurogenesis. Ciliopathies, syndromes resulting from a genetic disorder of cilial components, frequently have complex effects involving many organ systems, owing to the broad distribution of cilia in the body.

Original languageEnglish
Pages (from-to)324-336
Number of pages13
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume85
Issue number8
DOIs
Publication statusPublished - 2009 Oct
Externally publishedYes

Keywords

  • Cilia
  • Ciliopathy
  • Morphogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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