Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus

Fumiyuki Goto, Juri Saruta, Sho Kanzaki, Masahiro To, Tomoko Tsutsumi, Keiichi Tsukinoki, Kaoru Ogawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: Thus far, no objective measure has been developed to evaluate tinnitus severity. There is a close relationship between tinnitus and depression, in which brain-derived neurotrophic factor (BDNF) has a pathophysiological role. To determine whether BDNF levels could be used to evaluate tinnitus severity, we evaluated plasma BDNF levels in patients with tinnitus. Methods: Plasma BDNF levels were measured in 43 tinnitus patients and 30 healthy control patients. The severities of tinnitus, depression, and anxiety were measured using the tinnitus handicap inventory (THI) and the hospital anxiety and depression scale (HADS), respectively. Patients with tinnitus were divided into 2 groups depending on their THI scores: mildly handicapped (<36) and severely handicapped (>38). We also divided our subjects into 2 groups depending on the HADS score, which represents patient mood, including depression and anxiety. Results: Plasma BDNF levels were significantly higher in the mildly handicapped group than in the severely handicapped and control groups (P< 0.01). Patients with HADS scores of ≤14 had significantly lower THI scores (P< 0.05) and higher BDNF levels (P< 0.01). Conclusions: Our findings show for the first time that plasma BDNF levels vary with the severity of tinnitus, suggesting that plasma BDNF level is a useful tool for objective evaluation of tinnitus.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalNeuroscience Letters
Volume510
Issue number2
DOIs
Publication statusPublished - 2012 Feb 29

Fingerprint

Tinnitus
Brain-Derived Neurotrophic Factor
Depression
Anxiety
Disabled Persons
Hospital Inventories
Equipment and Supplies

Keywords

  • Depression
  • Plasma brain-derived neurotrophic factor
  • Tinnitus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus. / Goto, Fumiyuki; Saruta, Juri; Kanzaki, Sho; To, Masahiro; Tsutsumi, Tomoko; Tsukinoki, Keiichi; Ogawa, Kaoru.

In: Neuroscience Letters, Vol. 510, No. 2, 29.02.2012, p. 73-77.

Research output: Contribution to journalArticle

Goto, Fumiyuki ; Saruta, Juri ; Kanzaki, Sho ; To, Masahiro ; Tsutsumi, Tomoko ; Tsukinoki, Keiichi ; Ogawa, Kaoru. / Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus. In: Neuroscience Letters. 2012 ; Vol. 510, No. 2. pp. 73-77.
@article{85ece6f669ab458fa95a19d65841f092,
title = "Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus",
abstract = "Objective: Thus far, no objective measure has been developed to evaluate tinnitus severity. There is a close relationship between tinnitus and depression, in which brain-derived neurotrophic factor (BDNF) has a pathophysiological role. To determine whether BDNF levels could be used to evaluate tinnitus severity, we evaluated plasma BDNF levels in patients with tinnitus. Methods: Plasma BDNF levels were measured in 43 tinnitus patients and 30 healthy control patients. The severities of tinnitus, depression, and anxiety were measured using the tinnitus handicap inventory (THI) and the hospital anxiety and depression scale (HADS), respectively. Patients with tinnitus were divided into 2 groups depending on their THI scores: mildly handicapped (<36) and severely handicapped (>38). We also divided our subjects into 2 groups depending on the HADS score, which represents patient mood, including depression and anxiety. Results: Plasma BDNF levels were significantly higher in the mildly handicapped group than in the severely handicapped and control groups (P< 0.01). Patients with HADS scores of ≤14 had significantly lower THI scores (P< 0.05) and higher BDNF levels (P< 0.01). Conclusions: Our findings show for the first time that plasma BDNF levels vary with the severity of tinnitus, suggesting that plasma BDNF level is a useful tool for objective evaluation of tinnitus.",
keywords = "Depression, Plasma brain-derived neurotrophic factor, Tinnitus",
author = "Fumiyuki Goto and Juri Saruta and Sho Kanzaki and Masahiro To and Tomoko Tsutsumi and Keiichi Tsukinoki and Kaoru Ogawa",
year = "2012",
month = "2",
day = "29",
doi = "10.1016/j.neulet.2012.01.001",
language = "English",
volume = "510",
pages = "73--77",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus

AU - Goto, Fumiyuki

AU - Saruta, Juri

AU - Kanzaki, Sho

AU - To, Masahiro

AU - Tsutsumi, Tomoko

AU - Tsukinoki, Keiichi

AU - Ogawa, Kaoru

PY - 2012/2/29

Y1 - 2012/2/29

N2 - Objective: Thus far, no objective measure has been developed to evaluate tinnitus severity. There is a close relationship between tinnitus and depression, in which brain-derived neurotrophic factor (BDNF) has a pathophysiological role. To determine whether BDNF levels could be used to evaluate tinnitus severity, we evaluated plasma BDNF levels in patients with tinnitus. Methods: Plasma BDNF levels were measured in 43 tinnitus patients and 30 healthy control patients. The severities of tinnitus, depression, and anxiety were measured using the tinnitus handicap inventory (THI) and the hospital anxiety and depression scale (HADS), respectively. Patients with tinnitus were divided into 2 groups depending on their THI scores: mildly handicapped (<36) and severely handicapped (>38). We also divided our subjects into 2 groups depending on the HADS score, which represents patient mood, including depression and anxiety. Results: Plasma BDNF levels were significantly higher in the mildly handicapped group than in the severely handicapped and control groups (P< 0.01). Patients with HADS scores of ≤14 had significantly lower THI scores (P< 0.05) and higher BDNF levels (P< 0.01). Conclusions: Our findings show for the first time that plasma BDNF levels vary with the severity of tinnitus, suggesting that plasma BDNF level is a useful tool for objective evaluation of tinnitus.

AB - Objective: Thus far, no objective measure has been developed to evaluate tinnitus severity. There is a close relationship between tinnitus and depression, in which brain-derived neurotrophic factor (BDNF) has a pathophysiological role. To determine whether BDNF levels could be used to evaluate tinnitus severity, we evaluated plasma BDNF levels in patients with tinnitus. Methods: Plasma BDNF levels were measured in 43 tinnitus patients and 30 healthy control patients. The severities of tinnitus, depression, and anxiety were measured using the tinnitus handicap inventory (THI) and the hospital anxiety and depression scale (HADS), respectively. Patients with tinnitus were divided into 2 groups depending on their THI scores: mildly handicapped (<36) and severely handicapped (>38). We also divided our subjects into 2 groups depending on the HADS score, which represents patient mood, including depression and anxiety. Results: Plasma BDNF levels were significantly higher in the mildly handicapped group than in the severely handicapped and control groups (P< 0.01). Patients with HADS scores of ≤14 had significantly lower THI scores (P< 0.05) and higher BDNF levels (P< 0.01). Conclusions: Our findings show for the first time that plasma BDNF levels vary with the severity of tinnitus, suggesting that plasma BDNF level is a useful tool for objective evaluation of tinnitus.

KW - Depression

KW - Plasma brain-derived neurotrophic factor

KW - Tinnitus

UR - http://www.scopus.com/inward/record.url?scp=84856774977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856774977&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2012.01.001

DO - 10.1016/j.neulet.2012.01.001

M3 - Article

VL - 510

SP - 73

EP - 77

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -