Abstract
Many agents which induce apoptosis are either oxidants or stimulators of cellular oxidative metabolism. Conversely, many inhibitors of apoptosis including ADF/human thioredoxin, have antioxidant activities or enhance cellular antioxidant defenses. Cells exist in a state of oxidative siege in which survival requires an appropriate balance of oxidants and antioxidants. Eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis. ATL-derived factor (ADF) was first defined as the IL-2 Rα-inducing factor produced by ATF cell lines. Subsequent purification and gene cloning of ADF proved that it is a human homologue of the bacterial coenzyme thioredoxin. ADF has strong thiol-related reducing activities and also has multiple functions on various cell types. In this article, we introduce recent findings concerning 1) cytoprotective function of ADF, especially the cytoprotective effect of ADF on thiol-depleted lymphocytes, 2) redox regulation of signal transduction especially of tyrosine phosphorylation, and 3) translocation of ADF/TRX in response to some stress. We would like to discuss the importance of this subject in basic and clinical medicine.
| Original language | English |
|---|---|
| Pages (from-to) | 140-146 |
| Number of pages | 7 |
| Journal | Biotherapy |
| Volume | 9 |
| Issue number | 2 |
| Publication status | Published - 1995 |
| Externally published | Yes |
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Keywords
- ATL-derived factor (ADF)/thioredoxin
- cytoprotection
- signal transduction
- thiol compounds
ASJC Scopus subject areas
- Cancer Research
- Immunology and Allergy
Cite this
Various regulation of adult T cell leukemia-derived factor (ADF)/human thioredoxin expression and its cytoprotective action. / Yashiki, Y.; Furuke, K.; Maruyama, Tetsuo; Sato, N.; Hirota, K.; Nakamura, K.; Iwata, S.; Yodoi, J.
In: Biotherapy, Vol. 9, No. 2, 1995, p. 140-146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Various regulation of adult T cell leukemia-derived factor (ADF)/human thioredoxin expression and its cytoprotective action
AU - Yashiki, Y.
AU - Furuke, K.
AU - Maruyama, Tetsuo
AU - Sato, N.
AU - Hirota, K.
AU - Nakamura, K.
AU - Iwata, S.
AU - Yodoi, J.
PY - 1995
Y1 - 1995
N2 - Many agents which induce apoptosis are either oxidants or stimulators of cellular oxidative metabolism. Conversely, many inhibitors of apoptosis including ADF/human thioredoxin, have antioxidant activities or enhance cellular antioxidant defenses. Cells exist in a state of oxidative siege in which survival requires an appropriate balance of oxidants and antioxidants. Eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis. ATL-derived factor (ADF) was first defined as the IL-2 Rα-inducing factor produced by ATF cell lines. Subsequent purification and gene cloning of ADF proved that it is a human homologue of the bacterial coenzyme thioredoxin. ADF has strong thiol-related reducing activities and also has multiple functions on various cell types. In this article, we introduce recent findings concerning 1) cytoprotective function of ADF, especially the cytoprotective effect of ADF on thiol-depleted lymphocytes, 2) redox regulation of signal transduction especially of tyrosine phosphorylation, and 3) translocation of ADF/TRX in response to some stress. We would like to discuss the importance of this subject in basic and clinical medicine.
AB - Many agents which induce apoptosis are either oxidants or stimulators of cellular oxidative metabolism. Conversely, many inhibitors of apoptosis including ADF/human thioredoxin, have antioxidant activities or enhance cellular antioxidant defenses. Cells exist in a state of oxidative siege in which survival requires an appropriate balance of oxidants and antioxidants. Eukaryotic cells may benefit from this perilous existence by invoking oxidative stress as a common mediator of apoptosis. ATL-derived factor (ADF) was first defined as the IL-2 Rα-inducing factor produced by ATF cell lines. Subsequent purification and gene cloning of ADF proved that it is a human homologue of the bacterial coenzyme thioredoxin. ADF has strong thiol-related reducing activities and also has multiple functions on various cell types. In this article, we introduce recent findings concerning 1) cytoprotective function of ADF, especially the cytoprotective effect of ADF on thiol-depleted lymphocytes, 2) redox regulation of signal transduction especially of tyrosine phosphorylation, and 3) translocation of ADF/TRX in response to some stress. We would like to discuss the importance of this subject in basic and clinical medicine.
KW - ATL-derived factor (ADF)/thioredoxin
KW - cytoprotection
KW - signal transduction
KW - thiol compounds
UR - http://www.scopus.com/inward/record.url?scp=0028800828&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028800828&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028800828
VL - 9
SP - 140
EP - 146
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 2
ER -