Vascular stress response and endothelial vasoactive factors for vascular remodelling

Hiroshi Itoh, Kazuwa Nakao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In response to several vascular stresses caused by hyperglycaemia, hypertension or hyperlipidemia, endothelial cells (EC) sense these stresses as oxidative stress to secrete several autocrine/paracrine factors, including growth factors/cytokines and vasoactive peptides to regulate vascular tone and remodelling. Vascular stresses induce co-ordinate gene regulation of endothelial vasoactive substances and their related enzymes to cause vasorelaxation and vascular growth inhibition. We speculate that prolonged and excessive vascular stresses impair endothelial function, which results in the imbalance of endothelial production of vasoactive substances and leads to the formation of proliferative vascular lesions.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalDiabetes Research and Clinical Practice
Volume45
Issue number2-3
DOIs
Publication statusPublished - 1999 Sep
Externally publishedYes

Fingerprint

Blood Vessels
Hyperlipidemias
Vasodilation
Hyperglycemia
Intercellular Signaling Peptides and Proteins
Oxidative Stress
Endothelial Cells
Vascular Remodeling
Cytokines
Hypertension
Peptides
Enzymes
Growth
Genes

Keywords

  • Endothelial cells
  • Oxidative stress
  • Shear stress
  • Vasoactive substances

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Vascular stress response and endothelial vasoactive factors for vascular remodelling. / Itoh, Hiroshi; Nakao, Kazuwa.

In: Diabetes Research and Clinical Practice, Vol. 45, No. 2-3, 09.1999, p. 83-88.

Research output: Contribution to journalArticle

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