Vasculitis associated with septicemia: Case report and review of the literature

K. Kodo, M. Hida, S. Omori, T. Mori, M. Tokumura, S. Kuramochi, M. Awazu

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Abstract

We report an unusual case in which infectious endocarditis presented systemic vasculitis and glomerulonephritis as the initial manifestation of the disease. The patient was a 16-year-old girl with congenital cyanotic heart disease who presented with skin purpura, proteinuria, and hematuria. She had hypergammaglobulinemia, cryoglobulinemia, and positive circulating immune complexes. Renal biopsy revealed crescentic glomerulonephritis. Her serum C3 level, which was initially normal, became decreased, and prednisolone and azathioprine were administered with a tentative diagnosis of systemic lupus erythematosus (SLE). Soon after, she developed fever and renal failure. Blood culture grew Streptococcus pyogenes, and the diagnosis of infectious endocarditis was made. Eight cases of systemic vasculitis and glomerulonephritis associated with infectious endocarditis have been described in the literature. Infectious endocarditis should be included in the differential diagnosis of systemic vasculitis and glomerulonephritis.

Original languageEnglish
Pages (from-to)1089-1092
Number of pages4
JournalPediatric Nephrology
Volume16
Issue number12
DOIs
Publication statusPublished - 2001 Dec 1

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Keywords

  • Crescentic glomerulonephritis
  • Infectious endocarditis
  • Purpura
  • Rapidly progressive glomerulonephritis
  • Systemic vasculitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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