TY - JOUR
T1 - Vasoactive intestinal polypeptide and acetylcholine coexist with neuropeptide Y, dopamine-β-hydroxylase, tyrosine hydroxylase, substance P or calcitonin gene-related peptide in neuronal subpopulations in cranial parasympathetic ganglia of rat
AU - Hardebo, J. E.
AU - Suzuki, N.
AU - Ekblad, E.
AU - Owman, C.
PY - 1992/2
Y1 - 1992/2
N2 - Immunohistochemistry has been used to demonstrate that neuropeptide Y, dopamine-β-hydroxylase, calcitonin gene-related peptide or substance P are colocalized with vasoactive intestinal polypeptide and choline acetyltransferase in subpopulations of neurons in cranial parasympathetic ganglia of rat. These comprise the ciliary, sphenopalatine, otic, glossopharyngeal-vagal and internal carotid ganglia. In the ciliary and glossopharyngeal-vagal ganglia tyrosine hydroxylase is also found in such neurons. The findings emphasize that the combined localization of dopamine-β-hydroxylase and neuropeptide Y or the presence of tyrosine hydroxylase is not exclusively a marker for peripheral adrenergic neurons. Further, the co-localization of calcitonin gene-related peptide and substance P is not a decisive indication that a neuron is sensory in nature. It is discussed whether the presence of the enzymes and peptides other than vasoactive intestinal polypeptide is a remnant of a different expresion during ontogenesis or indicates target-specific functions in the adult.
AB - Immunohistochemistry has been used to demonstrate that neuropeptide Y, dopamine-β-hydroxylase, calcitonin gene-related peptide or substance P are colocalized with vasoactive intestinal polypeptide and choline acetyltransferase in subpopulations of neurons in cranial parasympathetic ganglia of rat. These comprise the ciliary, sphenopalatine, otic, glossopharyngeal-vagal and internal carotid ganglia. In the ciliary and glossopharyngeal-vagal ganglia tyrosine hydroxylase is also found in such neurons. The findings emphasize that the combined localization of dopamine-β-hydroxylase and neuropeptide Y or the presence of tyrosine hydroxylase is not exclusively a marker for peripheral adrenergic neurons. Further, the co-localization of calcitonin gene-related peptide and substance P is not a decisive indication that a neuron is sensory in nature. It is discussed whether the presence of the enzymes and peptides other than vasoactive intestinal polypeptide is a remnant of a different expresion during ontogenesis or indicates target-specific functions in the adult.
KW - Acetylcholine
KW - Calcitonin gene-related peptide
KW - Cranial autonomic ganglia
KW - Rat (Sprague-Dawley)
KW - Substance P
KW - Tyrosine hydroxylase
KW - Vasoactive intestinal polypeptide
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U2 - 10.1007/BF00302967
DO - 10.1007/BF00302967
M3 - Article
C2 - 1350946
AN - SCOPUS:0026564770
VL - 267
SP - 291
EP - 300
JO - Zeitschrift für Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)
JF - Zeitschrift für Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948)
SN - 0302-766X
IS - 2
ER -