Vasoactive intestinal polypeptide and acetylcholine coexist with neuropeptide Y, dopamine-β-hydroxylase, tyrosine hydroxylase, substance P or calcitonin gene-related peptide in neuronal subpopulations in cranial parasympathetic ganglia of rat

J. E. Hardebo, N. Suzuki, E. Ekblad, C. Owman

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

Immunohistochemistry has been used to demonstrate that neuropeptide Y, dopamine-β-hydroxylase, calcitonin gene-related peptide or substance P are colocalized with vasoactive intestinal polypeptide and choline acetyltransferase in subpopulations of neurons in cranial parasympathetic ganglia of rat. These comprise the ciliary, sphenopalatine, otic, glossopharyngeal-vagal and internal carotid ganglia. In the ciliary and glossopharyngeal-vagal ganglia tyrosine hydroxylase is also found in such neurons. The findings emphasize that the combined localization of dopamine-β-hydroxylase and neuropeptide Y or the presence of tyrosine hydroxylase is not exclusively a marker for peripheral adrenergic neurons. Further, the co-localization of calcitonin gene-related peptide and substance P is not a decisive indication that a neuron is sensory in nature. It is discussed whether the presence of the enzymes and peptides other than vasoactive intestinal polypeptide is a remnant of a different expresion during ontogenesis or indicates target-specific functions in the adult.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalCell and Tissue Research
Volume267
Issue number2
DOIs
Publication statusPublished - 1992 Feb 1

Keywords

  • Acetylcholine
  • Calcitonin gene-related peptide
  • Cranial autonomic ganglia
  • Rat (Sprague-Dawley)
  • Substance P
  • Tyrosine hydroxylase
  • Vasoactive intestinal polypeptide

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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