Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect

Yuji M.D. Morimoto, Hirotaka M.D. Matsuo, Tsunenori M.D. Arai, Makoto Kikuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We examined a participation of photochemical nitric oxide in the vasorelaxation induced by ultraviolet pulsed light. We measured a luminal diameter of rat femoral artery in vivo during a Krypton-fluoride (KrF) excimer laser irradiation. We also measured the vascular response when the artery was pretreated with sodium nitrite, superoxide dismutase or methylene blue. Histological changes in the vessels were examined by light microscopy. The vessel relaxed by KrF laser. The vasorelaxation was dependent on the repetition rate under the constant total energy. On the contrary, the vessel wall damage was inversely proportional to the repetition rate. Accordingly, the damage is most likely due to photoacoustic mechanism. The vasorelaxation was inhibited by methylene blue but enhanced by sodium nitrite or superoxide dismutase, which strongly suggests that the relaxation is closely related to nitric oxide. We conclude that the photochemical product of nitric oxide may be one of the possible mechanisms for the pulsed ultraviolet light induced vasorelaxation.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages298-301
Number of pages4
ISBN (Print)0819423866
Publication statusPublished - 1997 Dec 1
EventLaser-Tissue Interaction VIII - San Jose, CA, USA
Duration: 1997 Feb 91997 Feb 12

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2975
ISSN (Print)0277-786X

Other

OtherLaser-Tissue Interaction VIII
CitySan Jose, CA, USA
Period97/2/997/2/12

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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