Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect

Yuji M D Morimoto, Hirotaka M D Matsuo, Tsunenori Arai, Makoto Kikuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We examined a participation of photochemical nitric oxide in the vasorelaxation induced by ultraviolet pulsed light. We measured a luminal diameter of rat femoral artery in vivo during a Krypton-fluoride (KrF) excimer laser irradiation. We also measured the vascular response when the artery was pretreated with sodium nitrite, superoxide dismutase or methylene blue. Histological changes in the vessels were examined by light microscopy. The vessel relaxed by KrF laser. The vasorelaxation was dependent on the repetition rate under the constant total energy. On the contrary, the vessel wall damage was inversely proportional to the repetition rate. Accordingly, the damage is most likely due to photoacoustic mechanism. The vasorelaxation was inhibited by methylene blue but enhanced by sodium nitrite or superoxide dismutase, which strongly suggests that the relaxation is closely related to nitric oxide. We conclude that the photochemical product of nitric oxide may be one of the possible mechanisms for the pulsed ultraviolet light induced vasorelaxation.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages298-301
Number of pages4
Volume2975
ISBN (Print)0819423866
Publication statusPublished - 1997
Externally publishedYes
EventLaser-Tissue Interaction VIII - San Jose, CA, USA
Duration: 1997 Feb 91997 Feb 12

Other

OtherLaser-Tissue Interaction VIII
CitySan Jose, CA, USA
Period97/2/997/2/12

Fingerprint

Wave effects
Photoacoustic effect
Nitric oxide
krypton fluoride lasers
nitric oxide
ultraviolet radiation
vessels
inorganic peroxides
nitrites
methylene blue
Irradiation
arteries
Krypton
irradiation
repetition
sodium
damage
Sodium
excimer lasers
rats

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Morimoto, Y. M. D., Matsuo, H. M. D., Arai, T., & Kikuchi, M. (1997). Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2975, pp. 298-301). Society of Photo-Optical Instrumentation Engineers.

Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo : involvement of photochemical nitric oxide and photoacoustic wave effect. / Morimoto, Yuji M D; Matsuo, Hirotaka M D; Arai, Tsunenori; Kikuchi, Makoto.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2975 Society of Photo-Optical Instrumentation Engineers, 1997. p. 298-301.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Morimoto, YMD, Matsuo, HMD, Arai, T & Kikuchi, M 1997, Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 2975, Society of Photo-Optical Instrumentation Engineers, pp. 298-301, Laser-Tissue Interaction VIII, San Jose, CA, USA, 97/2/9.
Morimoto YMD, Matsuo HMD, Arai T, Kikuchi M. Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo: involvement of photochemical nitric oxide and photoacoustic wave effect. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2975. Society of Photo-Optical Instrumentation Engineers. 1997. p. 298-301
Morimoto, Yuji M D ; Matsuo, Hirotaka M D ; Arai, Tsunenori ; Kikuchi, Makoto. / Vasorelaxation induced by pulsed ultraviolet light irradiation in vivo : involvement of photochemical nitric oxide and photoacoustic wave effect. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2975 Society of Photo-Optical Instrumentation Engineers, 1997. pp. 298-301
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