Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line

Taiko Oda; Michio Namikoshi; Kyoko Akano; Hisayoshi Kobayashi; Yoshio Honma; Tadashi Kasahara

doi:10.3390/md302064

Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line

Taiko Oda, Michio Namikoshi, Kyoko Akano, Hisayoshi Kobayashi, Yoshio Honma, Tadashi Kasahara

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.

Original language	English
Pages (from-to)	64-73
Number of pages	10
Journal	Marine Drugs
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/md302064
Publication status	Published - 2005 Jun 2
Externally published	Yes

Keywords

HL-60
JNK-phosphorylation
MAP kinase
Verrucarin A
p38-phosphorylation

ASJC Scopus subject areas

Drug Discovery

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10.3390/md302064

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abstract = "Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.",

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T1 - Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line

AU - Oda, Taiko

AU - Namikoshi, Michio

AU - Akano, Kyoko

AU - Kobayashi, Hisayoshi

AU - Honma, Yoshio

AU - Kasahara, Tadashi

PY - 2005/6/2

Y1 - 2005/6/2

N2 - Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.

AB - Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.

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KW - MAP kinase

KW - Verrucarin A

KW - p38-phosphorylation

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Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line

Abstract

Keywords

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