Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line

Taiko Oda, Michio Namikoshi, Kyoko Akano, Hisayoshi Kobayashi, Yoshio Honma, Tadashi Kasahara

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Verrucarin A is an inhibitor of protein synthesis. In this study, we examined the inhibitory action of verrucarin A on signal molecules. Verrucarin A partially inhibited the IL-8 production of a PMA-stimulated promyelocytic leukemia cell line (HL-60 cells), and the effect was related to the inhibition of NF-κB activation at non-cytotoxic concentrations. Moreover, the inhibition of mitogen activated protein (MAP) kinase by verrucarin A was especially strong with p38- and JNK-phosphorylation. The findings show a new action of verrucarin A, and it is expected that this action relaxes the signal activation in response to stress.

Original languageEnglish
Pages (from-to)64-73
Number of pages10
JournalMarine Drugs
Volume3
Issue number2
DOIs
Publication statusPublished - 2005 Jun 2

Keywords

  • HL-60
  • JNK-phosphorylation
  • MAP kinase
  • Verrucarin A
  • p38-phosphorylation

ASJC Scopus subject areas

  • Drug Discovery

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    Oda, T., Namikoshi, M., Akano, K., Kobayashi, H., Honma, Y., & Kasahara, T. (2005). Verrucarin A inhibition of MAP kinase activation in a PMA-stimulated promyelocytic leukemia cell line. Marine Drugs, 3(2), 64-73. https://doi.org/10.3390/md302064