Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders

Philip Gerretsen, David D. Pothier, Carolyn Falls, Maxine Armstrong, Thushanthi Balakumar, Hiroyuki Uchida, David C. Mamo, Bruce G. Pollock, Ariel Graff-Guerrero

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Impaired insight into illness (IMP-INS) is common among individuals with schizophrenia spectrum disorders (SSD), contributing to medication nonadherence and poor clinical outcomes. Caloric vestibular simulation (CVS) is typically used to assess peripheral vestibular system function. Left cold CVS is also a transiently effective treatment for IMP-INS and hemineglect secondary to right brain hemisphere stroke, and possibly for IMP-INS and mood stabilization in patients with SSD. Participants with SSD and moderate-to-severe IMP-INS participated in an exploratory double blind, crossover, randomized controlled study of the effects of CVS on IMP-INS. Participants sequentially received all experimental conditions—left cold (4 °C), right cold, and body temperature/sham CVS—in a random order. Repeated measures ANOVA were performed to compare changes in IMP-INS, mood and positive symptom severity pre and 30 min post CVS. A significant interaction was found between CVS condition, time, and body temperature nystagmus peak slow phase velocity (PSPV) for IMP-INS, indicating that single session left cold CVS transiently improved IMP-INS while right cold CVS may have worsened IMP-INS, particularly in participants with greater vestibular reactivity (i.e. higher PSPV) to body temperature CVS. The procedure's effectiveness is attributed to stimulation of underactive right hemisphere circuits via vestibular nuclei projections to the contralateral hemisphere.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalPsychiatry Research
Volume251
DOIs
Publication statusPublished - 2017 May 1

Fingerprint

Schizophrenia
Body Temperature
Vestibular Nuclei
Medication Adherence
Analysis of Variance
Stroke
Brain
Therapeutics

Keywords

  • Anosognosia
  • Illness denial
  • Insight into illness
  • Schizophrenia
  • Vestibular stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Gerretsen, P., Pothier, D. D., Falls, C., Armstrong, M., Balakumar, T., Uchida, H., ... Graff-Guerrero, A. (2017). Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders. Psychiatry Research, 251, 333-341. https://doi.org/10.1016/j.psychres.2017.02.020

Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders. / Gerretsen, Philip; Pothier, David D.; Falls, Carolyn; Armstrong, Maxine; Balakumar, Thushanthi; Uchida, Hiroyuki; Mamo, David C.; Pollock, Bruce G.; Graff-Guerrero, Ariel.

In: Psychiatry Research, Vol. 251, 01.05.2017, p. 333-341.

Research output: Contribution to journalArticle

Gerretsen, P, Pothier, DD, Falls, C, Armstrong, M, Balakumar, T, Uchida, H, Mamo, DC, Pollock, BG & Graff-Guerrero, A 2017, 'Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders', Psychiatry Research, vol. 251, pp. 333-341. https://doi.org/10.1016/j.psychres.2017.02.020
Gerretsen, Philip ; Pothier, David D. ; Falls, Carolyn ; Armstrong, Maxine ; Balakumar, Thushanthi ; Uchida, Hiroyuki ; Mamo, David C. ; Pollock, Bruce G. ; Graff-Guerrero, Ariel. / Vestibular stimulation improves insight into illness in schizophrenia spectrum disorders. In: Psychiatry Research. 2017 ; Vol. 251. pp. 333-341.
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