Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

Xiaoyan Jiang, MacHelle T. Pardue, Kiwako Mori, Shin Ichi Ikeda, Hidemasa Torii, Shane D'Souza, Richard A. Lang, Toshihide Kurihara, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

Abstract

Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus-induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans.

Original languageEnglish
Article numbere2018840118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number22
DOIs
Publication statusPublished - 2021 Jun 1

Keywords

  • Myopia
  • Neuropsin (OPN5)
  • Nonvisual photoreceptors
  • Violet light

ASJC Scopus subject areas

  • General

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