Virucidal effect of the mesoscopic structure of cac-717 on severe acute respiratory syndrome coronavirus-2

Takashi Yokoyama, Tomoyasu Nishimura, Yoshifumi Uwamino, Kenjiro Kosaki, Koichi Furusaki, Rumiko Onishi, Takashi Onodera, Makoto Haritani, Katsuaki Sugiura, Rikio Kirisawa, Naoki Hasegawa

Research output: Contribution to journalArticlepeer-review

Abstract

Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this viru-cidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.

Original languageEnglish
Article number2096
JournalMicroorganisms
Volume9
Issue number10
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • CAC-717
  • Disinfectant
  • Mesoscopic structure
  • SARS-CoV-2

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology

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