Visante optical coherence tomography and tear function test evaluation of cholinergic treatment response in patients with Sjögren syndrome

Osama M.A. Ibrahim, Murat Dogru, Shinichi Kawashima, Tais H. Wakamatsu, Kazuo Tsubota, Hiroshi Fujishima

Research output: Contribution to journalArticle

7 Citations (Scopus)


Purpose: To evaluate tear meniscus changes in patients with Sjögren syndrome (SS) receiving oral pilocarpine with Visante optical coherence tomography (OCT). Methods: Eight patients with primary SS were recruited in this prospective interventional case series study. Patients received pilocarpine tablets twice a day for 3 months. Visual analog scale assessment for dry eye and dry mouth symptoms was carried out. Patients underwent OCT and slit-lamp microscopy graticule scale tear meniscus height (TMH) measurements, strip meniscometry testing, tear film breakup time measurement, fluorescein and Rose Bengal staining, and the Schirmer 1 test. The data were analyzed 1 week, 1 month, and 3 months after treatment. Mann-Whitney test was performed. Results: Visual analog scale assessment showed a significant time-wise improvement (P < 0.05). OCT and graticule scale TMH measurements significantly improved after 1 week (P < 0.05), 1 month, and 3 months of treatment (P < 0.001). Strip meniscometry, mean tear film stability, and fluorescein and Rose Bengal scores remained improved 3 months after treatment (P < 0.001), whereas Schirmer 1 test values tended to improve without statistical significance. Conclusions: Visante OCT was effective in monitoring tear meniscus changes during the course of treatment noninvasively and quickly. Oral pilocarpine seemed to be effective in improving TMH, and the signs and symptoms of dryness in patients with SS.

Original languageEnglish
Pages (from-to)653-657
Number of pages5
Issue number5
Publication statusPublished - 2013 May 1



  • Sjögren syndrome
  • cholinergic treatment
  • optical coherence tomography
  • tear meniscus height

ASJC Scopus subject areas

  • Ophthalmology

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