Visceral pleura invasion impact on non-small cell lung cancer patient survival: Its implications for the forthcoming tnm staging based on a large-scale nation-wide database

Junji Yoshida, Kanji Nagai, Hisao Asamura, Tomoyuki Goya, Yoshihiko Koshiishi, Yasunori Sohara, Kenji Eguchi, Masaki Mori, Yohichi Nakanishi, Ryosuke Tsuchiya, Etsuo Miyaoka

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

INTRODUCTION: No analyses have been reported on the impact of visceral pleura invasion (VPI) on staging, in relation with the International Association for the Study of Lung Cancer proposals for the 7th edition of the tumor, node, metastasis (TNM) classification of the International Union Against Cancer staging system. The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification. METHODS: We reviewed the data on 9758 non-small cell lung cancer patients, who underwent anatomic surgical resection in 1999, accumulated by the Japanese Joint Committee for Lung Cancer Registration, to gain insight into their clinicopathologic characteristics and outcomes. VPI was defined as tumor extension beyond the elastic layer of the visceral pleura. Patients were divided into nine groups according to VPI status and tumor diameter, in accordance with the International Association for the Study of Lung Cancer proposals. RESULTS: On the basis of survival, the nine groups were divided into the following five levels: tumors ≤2 cm without VPI; tumors ≤2 cm with VPI and tumors 2.1 to 3 cm without VPI; tumors 2.1 to 3 cm with VPI and tumors 3.1 to 5 cm without VPI; tumors 3.1 to 5 cm with VPI and tumors 5.1 to 7 cm without VPI; and tumors 5.1 to 7 cm with VPI and tumors >7 cm without VPI or T3 tumors. CONCLUSIONS: The T status of tumors, 7 cm or less, with VPI should be upgraded to the next T level in the future edition of the TNM classification of International Union Against Cancer staging system.

Original languageEnglish
Pages (from-to)959-963
Number of pages5
JournalJournal of Thoracic Oncology
Volume4
Issue number8
DOIs
Publication statusPublished - 2009 Aug
Externally publishedYes

Fingerprint

Pleura
Non-Small Cell Lung Carcinoma
Databases
Survival
Neoplasms
Neoplasm Metastasis

Keywords

  • Non-small cell lung cancer
  • Staging
  • TNM classification
  • Visceral pleura invasion

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Visceral pleura invasion impact on non-small cell lung cancer patient survival : Its implications for the forthcoming tnm staging based on a large-scale nation-wide database. / Yoshida, Junji; Nagai, Kanji; Asamura, Hisao; Goya, Tomoyuki; Koshiishi, Yoshihiko; Sohara, Yasunori; Eguchi, Kenji; Mori, Masaki; Nakanishi, Yohichi; Tsuchiya, Ryosuke; Miyaoka, Etsuo.

In: Journal of Thoracic Oncology, Vol. 4, No. 8, 08.2009, p. 959-963.

Research output: Contribution to journalArticle

Yoshida, Junji ; Nagai, Kanji ; Asamura, Hisao ; Goya, Tomoyuki ; Koshiishi, Yoshihiko ; Sohara, Yasunori ; Eguchi, Kenji ; Mori, Masaki ; Nakanishi, Yohichi ; Tsuchiya, Ryosuke ; Miyaoka, Etsuo. / Visceral pleura invasion impact on non-small cell lung cancer patient survival : Its implications for the forthcoming tnm staging based on a large-scale nation-wide database. In: Journal of Thoracic Oncology. 2009 ; Vol. 4, No. 8. pp. 959-963.
@article{fc94898f858842ea907e536daea184fb,
title = "Visceral pleura invasion impact on non-small cell lung cancer patient survival: Its implications for the forthcoming tnm staging based on a large-scale nation-wide database",
abstract = "INTRODUCTION: No analyses have been reported on the impact of visceral pleura invasion (VPI) on staging, in relation with the International Association for the Study of Lung Cancer proposals for the 7th edition of the tumor, node, metastasis (TNM) classification of the International Union Against Cancer staging system. The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification. METHODS: We reviewed the data on 9758 non-small cell lung cancer patients, who underwent anatomic surgical resection in 1999, accumulated by the Japanese Joint Committee for Lung Cancer Registration, to gain insight into their clinicopathologic characteristics and outcomes. VPI was defined as tumor extension beyond the elastic layer of the visceral pleura. Patients were divided into nine groups according to VPI status and tumor diameter, in accordance with the International Association for the Study of Lung Cancer proposals. RESULTS: On the basis of survival, the nine groups were divided into the following five levels: tumors ≤2 cm without VPI; tumors ≤2 cm with VPI and tumors 2.1 to 3 cm without VPI; tumors 2.1 to 3 cm with VPI and tumors 3.1 to 5 cm without VPI; tumors 3.1 to 5 cm with VPI and tumors 5.1 to 7 cm without VPI; and tumors 5.1 to 7 cm with VPI and tumors >7 cm without VPI or T3 tumors. CONCLUSIONS: The T status of tumors, 7 cm or less, with VPI should be upgraded to the next T level in the future edition of the TNM classification of International Union Against Cancer staging system.",
keywords = "Non-small cell lung cancer, Staging, TNM classification, Visceral pleura invasion",
author = "Junji Yoshida and Kanji Nagai and Hisao Asamura and Tomoyuki Goya and Yoshihiko Koshiishi and Yasunori Sohara and Kenji Eguchi and Masaki Mori and Yohichi Nakanishi and Ryosuke Tsuchiya and Etsuo Miyaoka",
year = "2009",
month = "8",
doi = "10.1097/JTO.0b013e3181a85d5e",
language = "English",
volume = "4",
pages = "959--963",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "8",

}

TY - JOUR

T1 - Visceral pleura invasion impact on non-small cell lung cancer patient survival

T2 - Its implications for the forthcoming tnm staging based on a large-scale nation-wide database

AU - Yoshida, Junji

AU - Nagai, Kanji

AU - Asamura, Hisao

AU - Goya, Tomoyuki

AU - Koshiishi, Yoshihiko

AU - Sohara, Yasunori

AU - Eguchi, Kenji

AU - Mori, Masaki

AU - Nakanishi, Yohichi

AU - Tsuchiya, Ryosuke

AU - Miyaoka, Etsuo

PY - 2009/8

Y1 - 2009/8

N2 - INTRODUCTION: No analyses have been reported on the impact of visceral pleura invasion (VPI) on staging, in relation with the International Association for the Study of Lung Cancer proposals for the 7th edition of the tumor, node, metastasis (TNM) classification of the International Union Against Cancer staging system. The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification. METHODS: We reviewed the data on 9758 non-small cell lung cancer patients, who underwent anatomic surgical resection in 1999, accumulated by the Japanese Joint Committee for Lung Cancer Registration, to gain insight into their clinicopathologic characteristics and outcomes. VPI was defined as tumor extension beyond the elastic layer of the visceral pleura. Patients were divided into nine groups according to VPI status and tumor diameter, in accordance with the International Association for the Study of Lung Cancer proposals. RESULTS: On the basis of survival, the nine groups were divided into the following five levels: tumors ≤2 cm without VPI; tumors ≤2 cm with VPI and tumors 2.1 to 3 cm without VPI; tumors 2.1 to 3 cm with VPI and tumors 3.1 to 5 cm without VPI; tumors 3.1 to 5 cm with VPI and tumors 5.1 to 7 cm without VPI; and tumors 5.1 to 7 cm with VPI and tumors >7 cm without VPI or T3 tumors. CONCLUSIONS: The T status of tumors, 7 cm or less, with VPI should be upgraded to the next T level in the future edition of the TNM classification of International Union Against Cancer staging system.

AB - INTRODUCTION: No analyses have been reported on the impact of visceral pleura invasion (VPI) on staging, in relation with the International Association for the Study of Lung Cancer proposals for the 7th edition of the tumor, node, metastasis (TNM) classification of the International Union Against Cancer staging system. The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification. METHODS: We reviewed the data on 9758 non-small cell lung cancer patients, who underwent anatomic surgical resection in 1999, accumulated by the Japanese Joint Committee for Lung Cancer Registration, to gain insight into their clinicopathologic characteristics and outcomes. VPI was defined as tumor extension beyond the elastic layer of the visceral pleura. Patients were divided into nine groups according to VPI status and tumor diameter, in accordance with the International Association for the Study of Lung Cancer proposals. RESULTS: On the basis of survival, the nine groups were divided into the following five levels: tumors ≤2 cm without VPI; tumors ≤2 cm with VPI and tumors 2.1 to 3 cm without VPI; tumors 2.1 to 3 cm with VPI and tumors 3.1 to 5 cm without VPI; tumors 3.1 to 5 cm with VPI and tumors 5.1 to 7 cm without VPI; and tumors 5.1 to 7 cm with VPI and tumors >7 cm without VPI or T3 tumors. CONCLUSIONS: The T status of tumors, 7 cm or less, with VPI should be upgraded to the next T level in the future edition of the TNM classification of International Union Against Cancer staging system.

KW - Non-small cell lung cancer

KW - Staging

KW - TNM classification

KW - Visceral pleura invasion

UR - http://www.scopus.com/inward/record.url?scp=68349086673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68349086673&partnerID=8YFLogxK

U2 - 10.1097/JTO.0b013e3181a85d5e

DO - 10.1097/JTO.0b013e3181a85d5e

M3 - Article

C2 - 19458555

AN - SCOPUS:68349086673

VL - 4

SP - 959

EP - 963

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 8

ER -