Abstract
We have developed a novel method for decarboxylative benzoyloxylation of β-hydroxy amino acids using photoredox catalyst Ru(bpy)<inf>3</inf>Cl<inf>2</inf>·6H<inf>2</inf>O and benzoylperoxide (BzO)<inf>2</inf>. This strategy was expanded to the synthesis of structurally diverse chiral 1,2-amino alcohols with different aryl or alkyl groups, starting from serine or threonine derivatives.
Original language | English |
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Pages (from-to) | 5787-5790 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue number | 42 |
DOIs | |
Publication status | Published - 2015 Oct 14 |
Keywords
- Amino alcohols
- N-Acyliminium
- Photocatalysis
- Ruthenium
- Visible light
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery