Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes

Yoshiko Motohashi, Satoru Yamada, Tatsuo Yanagawa, Taro Maruyama, Ryuji Suzuki, Masaaki Niino, Toshiyuki Fukazawa, Akira Kasuga, Hiroshi Hirose, Koichi Matsubara, Akira Shimada, Takao Saruta

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. We examined the VDR gene Bsm I polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. In conclusion, we found an association between a VDR gene polymorphism and acute-onset type 1 diabetes. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes.

Original languageEnglish
Pages (from-to)3137-3140
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number7
DOIs
Publication statusPublished - 2003 Jul 1

Fingerprint

Calcitriol Receptors
Medical problems
Polymorphism
Type 1 Diabetes Mellitus
Genes
T-cells
Gene Frequency
T-Lymphocytes
Autoimmune Diseases
Association reactions
Vitamin D
Autoantibodies
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Motohashi, Y., Yamada, S., Yanagawa, T., Maruyama, T., Suzuki, R., Niino, M., ... Saruta, T. (2003). Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 88(7), 3137-3140. https://doi.org/10.1210/jc.2002-021881

Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. / Motohashi, Yoshiko; Yamada, Satoru; Yanagawa, Tatsuo; Maruyama, Taro; Suzuki, Ryuji; Niino, Masaaki; Fukazawa, Toshiyuki; Kasuga, Akira; Hirose, Hiroshi; Matsubara, Koichi; Shimada, Akira; Saruta, Takao.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 7, 01.07.2003, p. 3137-3140.

Research output: Contribution to journalArticle

Motohashi, Y, Yamada, S, Yanagawa, T, Maruyama, T, Suzuki, R, Niino, M, Fukazawa, T, Kasuga, A, Hirose, H, Matsubara, K, Shimada, A & Saruta, T 2003, 'Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 7, pp. 3137-3140. https://doi.org/10.1210/jc.2002-021881
Motohashi, Yoshiko ; Yamada, Satoru ; Yanagawa, Tatsuo ; Maruyama, Taro ; Suzuki, Ryuji ; Niino, Masaaki ; Fukazawa, Toshiyuki ; Kasuga, Akira ; Hirose, Hiroshi ; Matsubara, Koichi ; Shimada, Akira ; Saruta, Takao. / Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. In: Journal of Clinical Endocrinology and Metabolism. 2003 ; Vol. 88, No. 7. pp. 3137-3140.
@article{75dc2583361e462fbda24fd6ee466f73,
title = "Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes",
abstract = "Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. We examined the VDR gene Bsm I polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. In conclusion, we found an association between a VDR gene polymorphism and acute-onset type 1 diabetes. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes.",
author = "Yoshiko Motohashi and Satoru Yamada and Tatsuo Yanagawa and Taro Maruyama and Ryuji Suzuki and Masaaki Niino and Toshiyuki Fukazawa and Akira Kasuga and Hiroshi Hirose and Koichi Matsubara and Akira Shimada and Takao Saruta",
year = "2003",
month = "7",
day = "1",
doi = "10.1210/jc.2002-021881",
language = "English",
volume = "88",
pages = "3137--3140",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "7",

}

TY - JOUR

T1 - Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes

AU - Motohashi, Yoshiko

AU - Yamada, Satoru

AU - Yanagawa, Tatsuo

AU - Maruyama, Taro

AU - Suzuki, Ryuji

AU - Niino, Masaaki

AU - Fukazawa, Toshiyuki

AU - Kasuga, Akira

AU - Hirose, Hiroshi

AU - Matsubara, Koichi

AU - Shimada, Akira

AU - Saruta, Takao

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. We examined the VDR gene Bsm I polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. In conclusion, we found an association between a VDR gene polymorphism and acute-onset type 1 diabetes. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes.

AB - Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. We examined the VDR gene Bsm I polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. In conclusion, we found an association between a VDR gene polymorphism and acute-onset type 1 diabetes. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0038637265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038637265&partnerID=8YFLogxK

U2 - 10.1210/jc.2002-021881

DO - 10.1210/jc.2002-021881

M3 - Article

C2 - 12843155

AN - SCOPUS:0038637265

VL - 88

SP - 3137

EP - 3140

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -