Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes

Yoshiko Motohashi, Satoru Yamada, Tatsuo Yanagawa, Taro Maruyama, Ryuji Suzuki, Masaaki Niino, Toshiyuki Fukazawa, Akira Kasuga, Hiroshi Hirose, Koichi Matsubara, Akira Shimada, Takao Saruta

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Abstract

Type 1 diabetes mellitus is recognized as a T-cell-mediated autoimmune disease. Vitamin D compounds are known to suppress T-cell activation by binding to the vitamin D receptor (VDR); and thus, VDR gene polymorphisms may be related to T-cell-mediated autoimmune diseases. We, therefore, investigated a VDR gene polymorphism in type 1 diabetes. We examined the VDR gene Bsm I polymorphism in 203 type 1 diabetic patients and 222 controls, and the association between the VDR gene polymorphism and type 1 diabetes and their onset pattern. We found a significantly higher frequency of B allele in type 1 diabetics overall, compared with controls (P = 0.0010). Moreover, there was a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls (P = 0.0002), whereas this difference was not observed between slow-onset type 1 diabetics and controls. Regardless of the existence of islet-associated autoantibody, we found a significant difference in B-allele frequency between acute-onset type 1 diabetics and controls. In conclusion, we found an association between a VDR gene polymorphism and acute-onset type 1 diabetes. Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes.

Original languageEnglish
Pages (from-to)3137-3140
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number7
DOIs
Publication statusPublished - 2003 Jul 1

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Motohashi, Y., Yamada, S., Yanagawa, T., Maruyama, T., Suzuki, R., Niino, M., Fukazawa, T., Kasuga, A., Hirose, H., Matsubara, K., Shimada, A., & Saruta, T. (2003). Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. Journal of Clinical Endocrinology and Metabolism, 88(7), 3137-3140. https://doi.org/10.1210/jc.2002-021881