VmrA, a member of a novel class of Na+-coupled multidrug efflux pumps from Vibrio parahaemolyticus

J. Chen, Y. Morita, M. N. Huda, T. Kuroda, T. Mizushima, T. Tsuchiya

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)


Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4′,6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na+/drug transporter activity because the addition of tetraphenylphosphonium to Na+-loaded cells caused Na+ efflux.

Original languageEnglish
Pages (from-to)572-576
Number of pages5
JournalJournal of Bacteriology
Issue number2
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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