Wavelength dependence of crosstalk in dual-wavelength measurement of oxy- and deoxy-hemoglobin

Nobuhiro Okui, Eiji Okada

    Research output: Contribution to journalArticle

    41 Citations (Scopus)

    Abstract

    In near-IR spectroscopy, the concentration change in oxyand deoxyhemoglobin in tissue is calculated from the change in the detected intensity of light at two wavelengths by solving the simultaneous equation based on the modified Lambert-Beer law. The wavelength-independent constant or mean optical path length is usually assigned to the term of partial optical path length in the simultaneous equation. This insufficient optical path length in the calculation causes crosstalk between the concentration change in oxy- and deoxyhemoglobin. We investigate the crosstalk in the dual-wavelength measurement of oxy- and deoxyhemoglobin theoretically by Monte Carlo simulation to discuss the optimal wavelength pair to minimize the crosstalk. The longer wavelength of the dual-wavelength measurement is fixed at 830 nm and the shorter wavelength is varied from 650 to 780 nm. The optimal wavelength range for pairing with 830 nm for the dual-wavelength measurement of oxy- and deoxyhemoglobin is from 690 to 750 nm. The mean optical path length, which can be obtained by time- and phase-resolved measurement, is effective to reduce the crosstalk in the results of dual-wavelength measurement.

    Original languageEnglish
    Article number011015
    JournalJournal of Biomedical Optics
    Volume10
    Issue number1
    DOIs
    Publication statusPublished - 2005 Jan 1

    Keywords

    • Crosstalk
    • Monte Carlo simulation
    • Near-infrared spectroscopy
    • Wavelength pair

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering

    Fingerprint Dive into the research topics of 'Wavelength dependence of crosstalk in dual-wavelength measurement of oxy- and deoxy-hemoglobin'. Together they form a unique fingerprint.

  • Cite this