WECHE: A novel hematopoietic regulatory factor

Osamu Ohneda, Kinuko Ohneda, Hisayuki Nomiyama, Zhong Zheng, Steven A. Gold, Fumio Arai, Takeshi Miyamoto, Bruce E. Taillon, Richard A. McIndoe, Richard A. Shimkets, David A. Lewin, Toshio Suda, Laurence A. Lasky

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29 Citations (Scopus)


Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effect on either myeloid or B cell formation. WECHE repressed BFU-E development from either mouse fetal liver or bone marrow progenitor cells but had no effect on colony formation induced by IL-3 or IL- 7. WECHE reduced HPP-CFC production from fetal liver-derived stem cells. WECHE hindered the growth of yolk sac-derived endothelial cells. WECHE was also chemotactic for bone marrow cells. Thus, WECHE is a novel chemokine that regulates hematopoietic differentiation.

Original languageEnglish
Pages (from-to)141-150
Number of pages10
Issue number2
Publication statusPublished - 2000 Feb
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Ohneda, O., Ohneda, K., Nomiyama, H., Zheng, Z., Gold, S. A., Arai, F., Miyamoto, T., Taillon, B. E., McIndoe, R. A., Shimkets, R. A., Lewin, D. A., Suda, T., & Lasky, L. A. (2000). WECHE: A novel hematopoietic regulatory factor. Immunity, 12(2), 141-150. https://doi.org/10.1016/s1074-7613(00)80167-3