Weight change and risk of developing type 2 diabetes

Yuko Oguma, Howard D. Sesso, Ralph S. Paffenbarger, I. Min Lee

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Objective: To examine the association between weight change and risk of type 2 diabetes and whether initial weight modifies the association. Research Methods and Procedures: This is a prospective cohort study of 20,187 alumni from Harvard University and the University of Pennsylvania. At baseline in 1962 or 1966, men (mean age, 45.9 years) reported their weight, height, and other risk factors. They also had had their weight and height measured at university entry (mean age, 18.5 years). Participants were followed from baseline to 1998 for type 2 diabetes. Results: During follow-up, 1223 men developed type 2 diabetes. Weight gain significantly increased the risk of this disease. The multivariate relative risks associated with BMI change from university entry to baseline of <-0.5, ±0.5, >0.5 to 1.0, > 1.0 to 1.5, > 1.5 to 2.0, >2.0 to 3.0, and >3.0 kg/m 2 per decade were 0.88, 1.00 (referent), 1.29, 2.09, 2.69, 4.67, and 7.02, respectively (p for trend < 0.0001). Even among men with a low initial BMI < 21 kg/m 2, weight gain significantly increased risk; the corresponding relative risks were (no cases), 1.00 (referent), 1.00, 1.93, 2.47, 4.82, and 7.68, respectively (p for trend < 0.0001). Discussion: A low initial BMI does not ameliorate the increase in risk of type 2 diabetes with weight gain. Avoidance of weight gain, even among lean individuals, is important to reduce the risk of this disease.

Original languageEnglish
Pages (from-to)945-951
Number of pages7
JournalObesity Research
Volume13
Issue number5
Publication statusPublished - 2005

Fingerprint

noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Weights and Measures
weight gain
Weight Gain
relative risk
research methods
cohort studies
risk factors
Cohort Studies
Prospective Studies
Research

Keywords

  • Epidemiology
  • Men
  • Type 2 diabetes
  • Weight gain
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Oguma, Y., Sesso, H. D., Paffenbarger, R. S., & Lee, I. M. (2005). Weight change and risk of developing type 2 diabetes. Obesity Research, 13(5), 945-951.

Weight change and risk of developing type 2 diabetes. / Oguma, Yuko; Sesso, Howard D.; Paffenbarger, Ralph S.; Lee, I. Min.

In: Obesity Research, Vol. 13, No. 5, 2005, p. 945-951.

Research output: Contribution to journalArticle

Oguma, Y, Sesso, HD, Paffenbarger, RS & Lee, IM 2005, 'Weight change and risk of developing type 2 diabetes', Obesity Research, vol. 13, no. 5, pp. 945-951.
Oguma Y, Sesso HD, Paffenbarger RS, Lee IM. Weight change and risk of developing type 2 diabetes. Obesity Research. 2005;13(5):945-951.
Oguma, Yuko ; Sesso, Howard D. ; Paffenbarger, Ralph S. ; Lee, I. Min. / Weight change and risk of developing type 2 diabetes. In: Obesity Research. 2005 ; Vol. 13, No. 5. pp. 945-951.
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