Weight growth velocity and neurodevelopmental outcomes in extremely low birth weight infants

Neonatal Research Network of Japan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). Methods Subjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). Results In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4- 11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. Conclusions WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.

Original languageEnglish
Article numbere0139014
JournalPLoS One
Volume10
Issue number9
DOIs
Publication statusPublished - 2015 Sep 24
Externally publishedYes

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Extremely Low Birth Weight Infant
low birth weight
Weights and Measures
Growth
confidence interval
Confidence Intervals
death
odds ratio
Odds Ratio
Parturition
Nutritional Support
nutritional support
Regression analysis
Logistics
Japan
Hospitalization

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Weight growth velocity and neurodevelopmental outcomes in extremely low birth weight infants. / Neonatal Research Network of Japan.

In: PLoS One, Vol. 10, No. 9, e0139014, 24.09.2015.

Research output: Contribution to journalArticle

Neonatal Research Network of Japan. / Weight growth velocity and neurodevelopmental outcomes in extremely low birth weight infants. In: PLoS One. 2015 ; Vol. 10, No. 9.
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abstract = "Introduction This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). Methods Subjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95{\%} confidence intervals (95{\%}CI). Results In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4- 11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95{\%}CI, 1.60-3.62) and 1.81 (95{\%}CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. Conclusions WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.",
author = "{Neonatal Research Network of Japan} and Hidehiko Maruyama and Naohiro Yonemoto and Yumi Kono and Satoshi Kusuda and Masanori Fujimura and M. Fujimura and S. Kusuda and S. Hattori and S. Konishi and T. Amizuka and T. Kasai and R. Takahashi and H. Arai and M. Satoh and Y. Miyazono and Y. Kono and T. Fujiu and H. Sobajima and K. Kabe and S. Hosono and M. Shiraishi and Y. Kawakami and T. Watanabe and Mariko Hida and K. Seki and H. Itani and A. Nemoto and T. Nakamura and O. Numata and Y. Ueno and Y. Kawano and S. Oki and C. Suzuki and M. Bonno and K. Nakamura and T. Yamakawa and M. Kihara and H. Wada and J. Shiraishi and H. Minami and A. Ohashi and H. Ichiba and T. Okutani and M. Miura and S. Watabe and R. Fukuhara and S. Kobayashi and S. Akiyoshi and T. Hisano and G. Kanda",
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AU - Neonatal Research Network of Japan

AU - Maruyama, Hidehiko

AU - Yonemoto, Naohiro

AU - Kono, Yumi

AU - Kusuda, Satoshi

AU - Fujimura, Masanori

AU - Fujimura, M.

AU - Kusuda, S.

AU - Hattori, S.

AU - Konishi, S.

AU - Amizuka, T.

AU - Kasai, T.

AU - Takahashi, R.

AU - Arai, H.

AU - Satoh, M.

AU - Miyazono, Y.

AU - Kono, Y.

AU - Fujiu, T.

AU - Sobajima, H.

AU - Kabe, K.

AU - Hosono, S.

AU - Shiraishi, M.

AU - Kawakami, Y.

AU - Watanabe, T.

AU - Hida, Mariko

AU - Seki, K.

AU - Itani, H.

AU - Nemoto, A.

AU - Nakamura, T.

AU - Numata, O.

AU - Ueno, Y.

AU - Kawano, Y.

AU - Oki, S.

AU - Suzuki, C.

AU - Bonno, M.

AU - Nakamura, K.

AU - Yamakawa, T.

AU - Kihara, M.

AU - Wada, H.

AU - Shiraishi, J.

AU - Minami, H.

AU - Ohashi, A.

AU - Ichiba, H.

AU - Okutani, T.

AU - Miura, M.

AU - Watabe, S.

AU - Fukuhara, R.

AU - Kobayashi, S.

AU - Akiyoshi, S.

AU - Hisano, T.

AU - Kanda, G.

PY - 2015/9/24

Y1 - 2015/9/24

N2 - Introduction This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). Methods Subjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). Results In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4- 11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. Conclusions WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.

AB - Introduction This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs). Methods Subjects were infants who weighed 501-1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003-2007). Patel's exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI). Results In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4- 11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60-3.62) and 1.81 (95%CI, 1.18-2.75), respectively, relative to the reference WGV score of 10. WGV scores ≥8 did not predict death or NDI. Conclusions WGV scores <8 were significant predictors suggesting that values of WGV during hospitalization in a NICU are associated with neurodevelopmental outcomes. Further investigations is necessary to determine whether additional nutritional support may improve low WGV in ELBWIs.

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